Bacterial infection and infection-induced immune response have been a life-threatening risk for patients having orthopedic implant surgeries. Conventional biomaterials are vulnerable to biocontamination, which causes bacterial invasion in wounded areas, leading to postoperative infection. Therefore, development of anti-infection and immune-evasive coating for orthopedic implants is urgently needed. Here, we developed an advanced surface modification technique for orthopedic implants termed lubricated orthopedic implant surface (LOIS), which was inspired by slippery surface of Nepenthes pitcher plant. LOIS presents a long-lasting, extreme liquid repellency against diverse liquids and biosubstances including cells, proteins, calcium, and bacteria. In addition, we confirmed mechanical durability against scratches and fixation force by simulating inevitable damages during surgical procedure ex vivo. The antibiofouling and anti-infection capability of LOIS were thoroughly investigated using an osteomyelitis femoral fracture model of rabbits. We envision that the LOIS with antibiofouling properties and mechanical durability is a step forward in infection-free orthopedic surgeries.
요약. 우리나라 동해안에 서식하는 염생식물 인 갯방풍으로부터 2개의 polyacetylene 화합물인 falcarindiol(1)과 falcarinol(2), 4개의 coumarin 화합물인 bergapten(3), xanthotoxin(4), umbelliferone(5), scopoletin(6) 및 1개의 sesquiterpene 화합물인 (5β,10α)-lasidiol angelate(7)가 분리되었다. 이들 화합물 중 scopoletin(6)과 (5β,10α)-Lasidiol angelate (7)
The Changhee polynomials and numbers are introduced by D.S. Kim et al in [5]. Some interesting identities and properties of those polynomials are derived from umbral calculus(see [5]). In this paper, we consider Witt-type formula for the weighted Changhee numbers and polynomials and derive some new interesting identities and properties of those polynomials and numbers from the Witt-type formula which are related to the weighted Euler polynomials.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.