Multiple query criteria active learning methods have a higher potential performance than conventional active learning methods in which only one criterion is deployed for sample selection. A central issue related to multiple query criteria active learning methods concerns the development of an integration criteria strategy that makes full use of all criteria. The conventional integration criteria strategies adopted in relevant research all facilitate the desired effects, but several limitations still must be addressed. For instance, some of the strategies are not sufficiently scalable during the design process, and the number and type of criteria involved are dictated. Thus, it is challenging for the user to integrate other criteria into the original process unless modifications are made to the algorithm. Other strategies are too dependent on empirical parameters, which can only be acquired by experience or cross-validation and thus lack generality; additionally, these strategies are counter to the intention of active learning, as samples need to be labeled in the validation set before the active learning process can begin.To address these limitations, we propose a novel multiple query criteria active learning method for classification tasks that employs a third strategy via weighted rank aggregation. The proposed method serves as a heuristic means to select high-value samples of high scalability and generality and is implemented through a three-step process: (1) the transformation of the sample selection to sample ranking and scoring, (2) the computation of the self-adaptive weights of each criterion, and (3) the weighted aggregation of each sample rank list. Ultimately, the sample at the top of the aggregated ranking list is the most comprehensively valuable and must be labeled. Several experiments generating 257 wins, 194 ties and 49 losses against other state-of-the-art multiple query criteria-based methods are conducted to verify that the proposed method can achieve superior results.
The prerequisite for establishing an effective prediction system for mammographic diagnosis is the annotation of each mammographic image. The manual annotation work is time-consuming and laborious, which becomes a great hindrance for researchers. In this article, we propose a novel active learning algorithm that can adequately address this problem, leading to the minimization of the labeling costs on the premise of guaranteed performance. Our proposed method is different from the existing active learning methods designed for the general problem as it is specifically designed for mammographic images. Through its modified discriminant functions and improved sample query criteria, the proposed method can fully utilize the pairing of mammographic images and select the most valuable images from both the mediolateral and craniocaudal views. Moreover, in order to extend active learning to the ordinal regression problem, which has no precedent in existing studies, but is essential for mammographic diagnosis (mammographic diagnosis is not only a classification task, but also an ordinal regression task for predicting an ordinal variable, viz. the malignancy risk of lesions), multiple sample query criteria need to be taken into consideration simultaneously. We formulate it as a criteria integration problem and further present an algorithm based on self-adaptive weighted rank aggregation to achieve a good solution. The efficacy of the proposed method was demonstrated on thousands of mammographic images from the digital database for screening mammography. The labeling costs of obtaining optimal performance in the classification and ordinal regression task respectively fell to 33.8 and 19.8 percent of their original costs. The proposed method also generated 1228 wins, 369 ties and 47 losses for the classification task, and 1933 wins, 258 ties and 185 losses for the ordinal regression task compared to the other state-of-the-art active learning algorithms. By taking the particularities of mammographic images, the proposed AL method can indeed reduce the manual annotation work to a great extent without sacrificing the performance of the prediction system for mammographic diagnosis.
The segmentation of coronary arteries by convolutional neural network is promising yet requires a large amount of laborintensive manual annotations. Transferring knowledge from retinal vessels in widely-available public labeled fundus images (FIs) has a potential to reduce the annotation requirement for coronary artery segmentation in X-ray angiograms (XAs) due to their common tubular structures. However, it is challenged by the cross-anatomy domain shift due to the intrinsically different vesselness characteristics in different anatomical regions under even different imaging protocols. To solve this problem, we propose a Semi-Supervised Cross-Anatomy Domain Adaptation (SS-CADA) which requires only limited annotations for coronary arteries in XAs. With the supervision from a small number of labeled XAs and publicly available labeled FIs, we propose a vesselness-specific batch normalization (VSBN) to individually normalize feature maps for them considering their different cross-anatomic vesselness characteristics. In addition, to further facilitate the annotation efficiency, we employ a self-ensembling mean-teacher (SE-MT) to exploit abundant unlabeled XAs by imposing a prediction consistency constraint. Extensive experiments show that our SS-CADA is able to solve the challenging cross-anatomy domain shift, achieving accurate segmentation for coronary arteries given only a small number of labeled XAs.
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