Due
to the inherent toxicity of cadmium selenide (CdSe)-based quantum
dots (QDs), Cd-free alternatives are being widely investigated. Indium
phosphide (InP) QDs have shown great potential as a replacement for
CdSe QDs in display applications. However, the performance of InP-based
quantum dot light-emitting diodes (QLEDs) is still far behind that
of the CdSe-based devices. In this study, we wanted to show the effects
of different approaches to improving the performance of InP-based
QLED devices. We investigated the effect of magnesium (Mg) doping
in ZnO nanoparticles, which is used as an n-type electron transport
layer, in balancing the charge transfer in InP-based QLED devices.
We found that an increasing Mg doping level can broaden ZnO band gap,
shift its energy levels, but most importantly, increase its resistivity;
as a result, the electron current density is significantly reduced
and the device efficiency is improved. We also investigated the effect
of high-photoluminescence quantum yield emitters and different QLED
architectures on the device performance. Through optimizing QD structures
and devices, red InP QLEDs with the current efficiencies as high as
11.6 cd/A were fabricated.
KAP1 is an universal corepressor for Kruppel-associated box zinc finger proteins in both normal and tumor cells. In this study, the biological function and clinical significance of KAP1 expression in ovarian cancer were investigated. Immunohistological staining of KAP1 was evaluated in 111 patients with ovarian epithelial cancer, 15 with ovarian borderline tumor, and 20 normal ovarian tissue. The correlations of KAP1 expression with clinicopathological features were studied. Kaplan-Meier analysis and Cox proportional hazard modeling were used to assess overall survival to analyze the effect of KAP1 expression on the prognosis of ovarian cancer. The positive rates of KAP1 were significantly higher in ovarian epithelial cancer (55.7%) and borderline tumor (20.0%) than in normal ovarian tissue (5.0%) (all p < 0.01). KAP1 expression correlated significantly with clinical stage (χ2 = 14.57, p < 0.0001), pathological grade (χ2 = 6.06, p = 0.048) and metastases (χ2 =10.38, p = 0.001). Patients with high KAP 1 levels showed poor survival (p < 0.0001). Multivariate analysis showed that KAP1 high expression was an independent predictor for ovarian cancer patients (hazard ratio = 0.463; 95% confidence interval = 0.230–0.9318, p = 0.031). Functionally, depletion of KAP1 by siRNA inhibited ovarian cancer cell proliferation, cell migration. KAP1 expression correlated with aggressive clinical features in ovarian cancer. High KAP1 expression was a prognostic factor of ovarian cancer.
A novel 316L type Cu-bearing stainless steel was developed in present work, aiming at reducing the occurrence of the in-stent restenosis after implantations of coronary stents, through trace amount of Cu release from surface of the steel in body fluid. It was found that there was a trace amount of Cu released from the Cu-bearing steel in a simulated body fluid, with no cytotoxicity. All the in vitro experimental results proved that this Cu-bearing steel could not only inhibit the proliferation of vascular smooth muscle cells, reducing the formation of thrombosis, which are the main reasons for happening of the in-stent restenosis, but also promote the proliferation of vascular endothelial cells needed for the revascularization, showing that this novel steel is prospective to be a new material for manufacturing coronary stents with function of reducing the in-stent restenosis.
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