Precise drug delivery in cancer treatment is a long-standing concern of modern medicine. Compared with traditional molecular medicines and nano-medicines, emerging cell-based biomimetic delivery strategies display numerous merits, including successive biological functions, innate biocompatibility and superior security since they originate from living organisms, providing a very promising approach. Among them, immune cells receive increasing attention because of their inherent ability in tumor resistance, pathogen elimination, and other significant physiological functions. Herein, we investigated the recent advances on immune cell-based high efficient delivery and therapeutic strategies in solid tumor treatment, mainly focus on T cells, NK cells and macrophages, which have been used as drug cargos directly or provided membrane/exosomes as nanoscale drug delivery systems. We also discuss the further potential applications and perspective of this innovative strategy, as well as the predictable challenges in forward exploration in this emerging area.
Using quantum theory and MATLAB software, the basic properties of two-dimensional linear harmonic oscillators in quantum mechanics are systematically studied in polar coordinate system, and obtain the visualized results. The results show that, in polar coordinate system, with the exception of special case nr
=0, |m|=0, the degeneracy of two-dimensional linear harmonic oscillator is 2nr
+|m|+1, and the corresponding energy eigenvalues is ħω (2nr
+|m|+1). The number of intersection line between wave function and the plane with ψ=0 is 2nr
+m. In the case of nr
=0, the maximum number of probability density distributions is 2|m|. The results of this visualization are in complete agreement with the theoretical results. The visualization results in different coordinate systems can be verified with each other, which opens up a new research idea and also provides an idea for other quantum theoretical models to be studied.
The main objective of this study was to preliminarily investigate the antibacterial activity and mechanism of action of Amomum tsao-ko (A. tsaoko) extracts against Bacillus subtilis and Listeria monocytogenes. The results showed that the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of A. tsaoko extracts against B. subtilis and L. monocytogenes were 1.25 mg/mL. Bacterial growth curves revealed that the A.tsaoko extracts had an obvious antibacterial activity against Bacillus subtilis and L. monocytogenes. Furthermore, the mechanism of action of A. tsaoko was evaluated by analyzing its effects on the integrity of cell membrane and cell morphology. The leakage of alkaline phosphatase (AKP) confirmed that the A. tsaoko extracts caused serious damage to the wall structure of B. subtilis and L. monocytogenes. Results of scanning electron microscopy (SEM) manifested that the destructive effect of A. tsaoko extracts on cell morphology and cell integrity of bacterial cells. The results implied that A. tsaoko extracts showed relatively good antibacterial effect on B. subtilis and L. monocytog.
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