A novel nanostructured catalyst of platinum nanoparticles supported on 5,10,15,20-tetrakis(1-methyl-4-pyridinio)porphyrin tetra(p-toluenesulfonate) (TMPyP) functionalized graphene (TMPyP-graphene) is synthesized by the hydrothermal polyol process. The as-synthesized nanocomposites are characterized by Fourier transform infrared (FTIR) spectroscopy, UV-vis absorption spectroscopy, Raman spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and electrochemical tests. It has been found that Pt nanoparticles of ca. 3.4 nm are uniformly dispersed on the surface of TMPyP-graphene, and hold a high electrochemical active surface area (ECSA) of 126.2 m(2) g(-1). The results demonstrate that the Pt/TMPyP-graphene catalyst exhibits a much higher electrocatalytic activity and stability than the Pt/graphene and commercial Pt/C catalysts for methanol oxidation, which is of significant importance in improving the efficiency of Pt-based electrocatalysts for DMFCs applications.
Cardiac hypertrophy is closely correlated with diverse cardiovascular diseases, augmenting the risk of heart failure and sudden death. Long non-coding RNAs (lncRNAs) have been studied in cardiac hypertrophy for their regulatory function. LncRNA MEG3 has been reported in human cancers. Whereas, it is unknown whether MEG3 regulates the growth of cardiac hypertrophy. Therefore, this study aims to investigate the specific role of MEG3 in the progression of cardiac hypertrophy. Here, we found that MEG3 contributed to the pathogenesis of cardiac hypertrophy. MEG3 expression was remarkably strengthened in the mice heart which undergone the transverse aortic constriction (TAC). Moreover, qRT-PCR analysis revealed that MEG3 was upregulated in the cardiomyocytes which were treated with Ang-II. Silenced MEG3 inhibited the increasing size of hypertrophic cardiomyocytes and reversed other hypertrophic responses. Mechanically, MEG3 could affect cardiac hypertrophy by regulating gene expression. Mechanically, we found that MEG3 could be upregulated by the transcription factor STAT3 and could regulate miR-361-5p and HDAC9 by acting as a ceRNA. Finally, rescue assays were made to do further confirmation. All our findings revealed that STAT3-inducetd upregulation of lncRNA MEG3 controls cardiac hypertrophy by regulating miR-362-5p/HDAC9 axis.
Metal oxide-based
nano/microstructures assembled on heteroatom-doped
carbon nanomaterials are promising materials to design the electrocatalysts
with enhanced electrochemical performances. In this work, a systematic
protocol was contrived to fabricate hybrid electrode material based
on Cu2O microspheres (MSs) supported on sulfur-doped multiwalled
carbon nanotubes (Cu2O MSs/S-MWCNTs). The adequate doping
of sulfur and successful fabrication of Cu2O MSs/S-MWCNTs
were confirmed by various microscopic and spectroscopic techniques,
and then the tailor-made Cu2O MSs/S-MWCNTs composite was
employed to establish a nonenzymatic sensing system for controlled
monitoring of glucose. A high surface area of Cu2O MSs
and sulfur doping inside the MWCNTs collectively enhanced the electrocatalytic
activity of Cu2O MSs/S-MWCNTs as revealed through cyclic
voltammetry (CV) analysis. The enhanced electrochemical efficacy of
Cu2O MSs/S-MWCNTs may be credited to the creation of heterojunctions
during the doping process, forming the highly defected structures
with increased number of catalytic active sites. In addition, the
Cu2O MSs/S-MWCNTs/GCE presented the good amperometric response
for glucose sensing attaining optimal linear range, satisfactory sensitivity,
excellent stability, and glucose specific selectivity. These unique
chemical and electrochemical features strongly encourage the potential
applicability of our designed Cu2O MSs/S-MWCNT electrocatalyst
for targeted monitoring of glucose.
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