The solubility of 2-cyanoacetamide in N,N-dimethylformamide, acetone, acetonitrile, methanol, methyl
acetate, tetrahydrofuran, ethanol, ethyl acetate, n-propanol, n-butanol, trichloromethane, dichloromethane,
1,4-dioxane, and water was measured by a laser dynamic method under
atmospheric pressure in the temperature range of (273.15–318.15)
K. The solubility order of 2-cyanoacetamide in selected solvents was N,N-dimethylformamide > acetone > water
> acetonitrile > methanol > methyl acetate >1,4-dioxane > tetrahydrofuran
> ethanol > ethyl acetate > n-propanol > n-butanol > trichloromethane > dichloromethane. Hansen solubility
parameters were used to explain and predict the solubility behavior
of 2-cyanoacetamide. The modified Apelblat equation, λh equation, NRTL model equation, and Wilson model were used to correlate
the experimental solubility data. The values of the RMSD (less than
0.005) and RAD (less than 0.2) indicated that the modified Apelblat
equation agreed well with the experimental values, compared to other
models. The values of Δmix
G, Δmix
S, Δmix
H, the activity coefficient, and the reduced excess enthalpy were
obtained on the basis of the Wilson model. The mixing process of 2-cyanoacetamide
in the studied solvents was a favorable and spontaneous process. The
and
values were not similar, which means that
2-cyanoacetamide in selected solvent solution systems was nonideal.