Optimal treatment for resectable esophageal squamous cell carcinoma (ESCC) is controversial, especially in the context of potential benefit of combining PD‐1 blockade with neoadjuvant therapy. This phase 2 study aimed to assess neoadjuvant camrelizumab plus chemotherapy in this population. Patients (clinical stage II‐IVA) received two cycles of neoadjuvant chemoimmunotherapy (NIC) with camrelizumab (200 mg on day 1) plus nab‐paclitaxel (260 mg/m2 in total on day 1 and day 8) and cisplatin (75 mg/m2 in total on days 1‐3) of each 21‐day cycle. Surgery was performed approximately 6 weeks after completion of NIC. Primary endpoint was complete pathologic response (CPR) rate in primary tumor. Secondary endpoints were objective response rate (ORR) per RECIST v1.1, 2‐year progression‐free survival (PFS) rate after surgery, PFS, overall survival (OS) and safety during NIC and perioperative period. Between 17 January 2020 and 8 December 2020, 56 patients were enrolled, and 51 received esophagectomy. Data cutoff date was 25 August 2021. The CPR rate was 35.3% (95% CI, 21.7%‐48.9%). NIC had an ORR of 66.7% (95% CI, 40.0%‐70.4%) and treatment‐related adverse events (TRAEs) of low severity (grade 1‐2, 75.0%; grade 3, 10.7%; grade 4‐5, no). No perioperative mortality occurred. Three (5.9%) patients had tumor recurrence and one (2.0%) patient died. The 2‐year PFS rate, median PFS and median OS had not been reached yet. Camrelizumab plus neoadjuvant chemotherapy in resectable ESCC demonstrates promising efficacy with acceptable toxicity, providing a feasible and effective option. Study is ongoing for long‐term survival analyses.
Mechanical behaviour of the soil around a jacked pile changes significantly during pile installation and subsequent consolidation. Hence, an axially loaded jacked pile exhibits apparent time-dependent bearing performance after pile installation. This paper presents a semi-analytical approach to predict the time-dependent bearing performance of an axially loaded jacked pile in saturated clay strata. The effects of pile installation and subsequent consolidation on the changes in mechanical properties of the surrounding soil are modeled by the cavity expansion theory and the radial consolidation theory, respectively. An exponential function–based load-transfer (t–z) curve is employed to describe the nonlinear behaviour of the pile–soil interface during pile loading. The evolutions of the three-dimensional strength and shear modulus of the surrounding soil are subsequently incorporated into the two model parameters of the proposed t–z curve to capture the time-dependent pile–soil interaction behaviour. The time-dependent elastic response of the soil outside the pile–soil interface is also considered in the proposed approach. With the proposed load-transfer curve, an incremental algorithm and a corresponding computational code are developed for assessing the time-dependent load–settlement response of a jacked pile. To verify the proposed semi-analytical approach, predictions of the time-dependent load–settlement curves are compared with the measured values from pile tests at two sites. The good agreement shows that the time-dependent bearing performance can be reasonably predicted by the proposed approach.
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