A cadmium sulfide quantum-dot-photocatalyzed C(sp 3 )ÀCl bond cleavage of ethyl chlorodifluoroacetate and cascade cyclization with unactivated olefins is described herein. This reaction provides a cost-efficient method for synthesizing a wide range of CF 2 -containing azaheterocycles from a variety of functionalized difluoromethyl chlorides. Furthermore, the results of a preliminary antiproliferative activity study indicate an in vitro antiproliferative activity superior to that of doxorubicin with IC 50 values of 1.140 mM on triple negative breast cancer (MDA-MB-231) and 2.129 mM on lung (A549) carcinoma cells.
Sulfonyl
oxime ethers undergo facile radical substitutions with
various amines to yield the corresponding oxime ethers. An efficient
arylation of sulfonyl oxime ethers was accomplished under ambient
temperature and metal-free conditions, with a wide range of functional
group tolerance. Mechanistic investigations indicate that a phenyl
radical is involved in the catalytic cycle.
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