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Autoimmune hepatitis is an interface hepatitis characterized by the progressive destruction of the liver parenchyma, the cause of which is still obscure. Interleukin (IL)‐17A is a major driver of autoimmunity, which can be produced by innate immune cells against several intracellular pathogens. Here, we investigated the involvement of IL‐17A in a mice model of immune‐mediated hepatitis with the intestine exposed to Salmonella typhimurium. Our results showed more severe Concanavalin (Con) A‐induced liver injury and gut microbiome dysbiosis when the mice were treated with a gavage of S. typhimurium. Then, the natural killer (NK) T cells were overactivated by the accumulated IL‐17A in the liver in the Con A and S. typhimurium administration group. IL‐17A could activate NKT cells by inducing CD178 expression via IL‐4/STAT6 signaling. Furthermore, via the portal tract, the laminae propria mucosal‐associated invariant T (MAIT)‐cell‐derived IL‐17A could be the original driver of NKT cell overactivation in intragastric administration of S. typhimurium and Con A injection. In IL‐17A‐deficient mice, Con A‐induced liver injury and NKT cell activation were alleviated. However, when AAV‐sh‐mIL‐17a was used to specifically knock down IL‐17A in liver, it seemed that hepatic IL‐17a knock down did not significantly influence the liver injury. Our results suggested that, under Con A‐induction, laminae propria MAIT‐derived IL‐17A activated hepatic NKT, and this axis could be a therapeutic target in autoimmune liver disease.

This study aims to ensure the wide application of ultrasound-guided superior brachial plexus block in shoulder surgery, solve the application problem of ultrasound-guided superior brachial plexus block in shoulder surgery, make up for severe postoperative pain after shoulder arthroscopy, and improve the patient's recovery ability. In this paper, 90 patients with shoulder arthroscopy were divided into 3 groups: A, B, and C. In recent years, with the rapid development of medicine, ultrasound-guided brachial plexus upper trunk block has been widely used in shoulder surgery. Shoulder arthroscopy is more and more used in the diagnosis and treatment of shoulder diseases because of its advantages of minimally invasive, safe, and rapid recovery. Compared with the traditional operation, it is found that the shoulder arthroscopic operation reduces the incision trauma through the microscope, but the shoulder operation involves more muscles and ligaments, so the perioperative pain of shoulder arthroscopic operation is still serious.