Ions (e.g.,
H
3
+
, H2O+) have been used extensively to quantify the cosmic-ray ionization rate (CRIR) in diffuse sightlines. However, measurements of the CRIR in low-to-intermediate density gas environments are rare, especially when background stars are absent. In this work, we combine molecular line observations of CO, OH, CH, and HCO+ in the star-forming cloud IC 348, and chemical models to constrain the value of the CRIR and study the response of the distribution of chemical abundances. The cloud boundary is found to have an A
V of approximately 4 mag. From the interior to the exterior of the cloud, the observed 13CO line intensities drop by an order of magnitude. The calculated average abundance of 12CO (assuming 12C/13C=65) is (1.2 ± 0.9) × 10−4, which decreases by a factor of 6 from the interior to the outside regions. The average abundance of CH (3.3 ± 0.7 × 10−8) is in good agreement with previous findings in diffuse and translucent clouds (A
V < 5 mag). However, we did not find a decline in CH abundance in regions of high extinction (A
V ≃ 8 mag) as previously reported in Taurus. By comparing the observed molecular abundances and chemical models, we find a decreasing trend of the CRIR as A
V increases. The inferred CRIR of ζ
cr = (4.7 ± 1.5) × 10−16 s−1 at low A
V is consistent with
H
3
+
measurements toward two nearby massive stars.
Background
Catheter-directed thrombolysis (CDT) has been an important therapy and seems effective in patients with splanchnic venous thrombosis (SVT) secondary to some diseases, but this intervention hasn’t been formally evaluated in the setting of acute pancreatitis (AP).
Methods
This was a retrospective study enrolled patients between January 2013 and December 2018. AP patients who developed SVT-induced symptoms, including intractable ascites and/or enteral nutrition intolerance, were included. Demographics, SVT associated parameters, clinical features and outcomes, long-term quality of life evaluated by using SF-36 questionnaire were compared between CDT group and systemic anticoagulation (SAC) group.
Results
6 patients underwent CDT and 17 received SAC. Patients in CDT group had a higher recanalization rate (100% versus 35.3%; p = 0.014) and shorter time to symptoms resolution (median 8 days versus. 31.5 days, p = 0.004). Mortality and length of hospital stay were comparable between two groups. The association analysis indicated that CDT use exerted a significantly beneficial effect on recanalization rate (risk ratio, 2.833; 95% CI, 1.489 to 5.393; p = 0.002) and time to symptoms resolution (mean difference, -33.333; 95% CI, -64.612 to -2.055; p = 0.038). No SVT-related symptoms recurrence was recorded in survivors at six-month follow-up. There was no statistical difference in either item of SF-36 questionnaire between two groups.
Conclusions
Compared with SAC, CDT may facilitate vascular recanalization and shorten symptom resolution for symptomatic SVT.
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