Aims:To evaluate the effect of tropicamide phenylephrine(TP) eyedrops on the retinal and choroidal vascular density and choroidal thickness.
Methods: A prospective clinical study was used. 72 myopic children and adolescents aged 4-14 years old were given TP eyedrops to dilate the pupil, and all participants were given relevant ophthalmological examination before and after pupil dilation. OCTA is used to scan the macular 3*3mm area with layered lines. Image J software was used to measure the retinal and choroidal vascular density at each layer and OCT enhanced depth imaging mode was performed for the subfoveal choroidal thickness assessment.
Results: Following instillation of the TP eyedrops, the superficial retinal vascular density was decreased (from28.67±4.11 to 26.47±6.47, p<0.001) significantly, the choroidal vascular density increased (from37.04±6.83 to 37.81±6.20,p<0.001) in the macular area, and the choroidal thickness of subfoveal increased (from 243.94±65.10 to 248.59±69.11,p<0.001). Through multivariate analysis, age was the main factor that affects the superficial retinal and choroidal vascular density and choroidal thickness.
Conclusion: TP eyedrops can significantly reduce the superficial retinal vascular density and increase the choroidal vascular density and choroidal thickness in children. Age is the main factor that affects the superficial retinal and choroidal vascular density and choroidal thickness.
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