Cordycicadins A–D (1–4)
are four novel polyketides that were isolated from the liquid fermentation
of the insect-pathogenic fungus Cordyceps cicadae JXCH1. The structures were determined by a combination of spectroscopic
analysis, single-crystal X-ray diffraction, and computational methods.
Compounds 1, 3, and 4 harbor
an unusual exocyclic enol ether bridge that connects the separated
ring systems. Hypothetical biosynthetic pathways for 1–4 were proposed. Cordycicadins A (1) and B (2) showed antifeedant activity against silkworm
larvae (Bombyx mori) with EC50 values of 65.4 and 57.0 μg/cm2, respectively.
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