A facile access to highly fused tetracyclic
indeno-1,2-benzothiazines
has been established via a Rh(III)-catalyzed C–H bond activation
and intramolecular annulation cascade between sulfoximides and all-carbon
diazo indandiones. This strategy is characterized by the fact that
the diazo coupling partners do not require preactivation, along with
its high efficiency, broad substrate generality, and facile transformation.
Particularly, the highly conjugated tetracyclic products demonstrate
good optical properties and can easily enter cells to emit bright
fluorescence for live cell imaging.
Peptidomimetic macrocycles often exhibit superior biological properties and druggability, leading to their versatile application in the pharmaceutical industry. A highly efficient and practical methodology for the functionalization and macrocyclization of...
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