One new 2-arylbenzo[b]furan named iteafuranal F (1) as well as two known analogues (2-3) were isolated from the 95% EtOH extract of aerial parts of Itea omeiensis. Their chemical structures were constructed based on extensive spectroscopic analyses including UV, IR, 1D/2D NMR and HRMS analyses.Antioxidant assays revealed that iteafuranal F (1) displayed significant superoxide anion radical scavenging capacity with IC 50 value of 0.66 mg/mL, which was comparable to the efficiency of positive control of luteolin. In addition, the preliminary fragmentation patterns of MS in negative ion mode were established to distinguish 2-arylbenzo[b]furans with C-10 in different oxidation states: the characteristic loss of CO molecule [M-H-28]was observed for 3-formyl-2-arylbenzo[b]furans, and the loss of CH 2 O fragment [M-H-30]for 3-hydroxymethyl-2-arylbenzo[b]furans, and the loss of CO 2 fragment [M-H-44]for 2-arylbenzo[b]furan-3-carboxylic acids.
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