Multiwalled boron carbonitride (BCN) nanotubes with two different structures were synthesized via thermal chemical vapor deposition; one has 10% C atoms homogeneously doped into BN nanotubes (B0.45C0.1N0.45 NTs), and the other has BN layers sheathed with 5-nm-thick C outerlayers (BN-C NTs). The electronic structures of the B, C, and N atoms were thoroughly probed by synchrotron X-ray photoelectron spectroscopy and the X-ray absorption near-edge structure method. The B0.45C0.1N0.45 NTs contain a significant amount of B-C and C-N bonding with a pyridine-like structure (hole structure), which reduces the pi bonding states of the B and N atoms. From the XPS valence band spectrum, the band gap was estimated to be about 2.8 eV. In the BN-C NTs, the C and BN domains are separated without forming the pyridine-like structure. Using the first principles method, we investigated the relative stabilities and electronic structures of the various isomers of the double-walled (12,0)@(20,0) BCN NTs. The C-outerlayer BN nanotube structure is the most stable isomer, when there exist no defects in the tubes with B/N = 1.0 (i.e., graphite-like structure). In addition, a reasonable model, which is characterized by the motives consisted of three pyridine-like rings around a hollow site, is presented for the local structure of C atoms in the B0.45N0.45C0.1 NTs. A considerable decrease of the band gap due to the 10% C doping was predicted, which was consistent with the experimental results.
A series of 5-N-methyl quindoline (cryptolepine) derivatives (2a- x) as telomeric quadruplex ligands was synthesized and evaluated. The designed ligands possess a positive charge at the 5- N position of the aromatic quindoline scaffold. The quadruplex binding of these compounds was evaluated by circular dichroism (CD) spectroscopy, fluorescence resonance energy transfer (FRET) melting assay, polymerase chain reaction (PCR) stop assay, nuclear magnetic resonance (NMR), and molecular modeling studies. Introduction of a positive charge not only significantly improved the binding ability but also induced the selectivity toward antiparallel quadruplex, whereas the nonmethylated derivatives tended to stabilize hybrid-type quadruplexes. NMR and molecular modeling studies revealed that the ligands stacked on the external G-quartets and the positively charged 5- N atom could contribute to the stabilizing ability. Long-term exposure of human cancer cells to 2r showed a remarkable cessation in population growth and cellular senescence phenotype and accompanied by a shortening of the telomere length.
Four isaindigotone derivatives (5a,b and 6a,b) designed as telomeric G-quadruplex ligands have been synthesized and characterized. The unfused aromatic rings in these compounds allow a flexible and adaptive conformation in G-quadruplex recognition. The interaction of human telomeric G-quadruplex DNA with these designed ligands was explored by means of FRET melting, fluorescence titration, CD spectroscopy, continuous variation, and molecular modeling studies. Our results showed that the adaptive scaffold might not only allow the ligands to well occupy the G-quartet but also perfectly bind to the grooves of the G-quadruplex. The synergetic effect of the multiple binding modes might be responsible for the improved binding ability and high selectivity of these ligands toward G-quadruplex over duplex DNA. Long-term exposure of HL60 and CA46 cancer cells to compound 5a showed a remarkable decrease in population growth, cellular senescence phenotype, and shortening of the telomere length, which is consistent with the behavior of an effective telomeric G-quadruplex ligand and telomerase inhibitor.
A combination of low-temperature scanning tunneling microscopy and density functional theory calculations was used to determine the binding characteristics of single pyridine molecules at a low coverage on a silver surface. The results indicated that pyridine binds to silver through the nitrogen atom in either a perpendicular or a parallel configuration with the latter structure being more prevalent. Both configurations are produced predominantly through electrostatic interaction between nitrogen and silver atoms. This is induced by charge redistribution in the pyridine molecule and nearby silver atoms upon pyridine adsorption.
A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell...
On the basis of calculations using density functional theory, we investigated the relative stabilities of all isomers of Sc3N@C67B and Sc3N@C67N as well as those of stable isomers of Sc3N@C66BN. As a result, we predict that Sc3N@C68 can be doped substitutionally with a boron atom much better than C60. This effect can be ascribed to the favorable electrostatic attraction between the encased Sc3N cluster and the polar C-B bonds of the fullerene cage, which show the important role played by the encapsulated atoms in stabilizing the fullerene. A difference in the interaction also determines the regiospecificity of Sc3N@C67B. On the contrary, N-doping of the fullerenes forming Sc3N@C67N is much less favorable than that in C60 or C70. A judicious choice of stable isomers of Sc3N@C66BN among a vast number of possible isomers indicates that Sc3N@C68 can also be doped with a pair of B and N atoms better than C60 under the simultaneous existence of B and N sources. Relative stabilities of various isomers of the BN-substituted fullerenes can be understood in terms of the combined electrostatic effects in the B- and N-substitutions of Sc3N@C68 complemented by a specific local preference in the N-substitution and the formation of a B-N bond.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.