The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin Graphical abstract Highlights d Clr4 is selectively sequestered by H3K9M at heterochromatin d H3K14ub synergizes with H3K9M to sequester Clr4 at heterochromatin in vivo d H3K14ub synergizes with H3K9M to promote interaction with Clr4 in vitro d H3K14ub changes the kinetics of the H3K9M-Clr4 interaction
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