Highlights d Longitudinal scRNA-seq of tumor-specific TCF-1 + CD8 + T cells in KP lung adenocarcinoma d Identified a proliferative Slamf6 + TCF-1 + T cell subset and a non-cycling SlamF6 À subset d The lymph node contains a recruitable reservoir of functional TCF-1 + CD8 + T cells d Flt3L+CD40 boosts cDC1, increases TCF-1 + CD8 + T cell frequencies, decreases tumor burden

Cardiorespiratory responses and pelvic kinematics are reproducible with SHBR in young children, and these responses were lower than those elicited by slow treadmill walking.

Direct-to-consumer (DTC) genetic tests have generated considerable scholarly attention and public intrigue. Although the current consumer genetic testing regime relies on the reporting of individual variants of interest to consumers, there has recently been interest in the possibility of integrating polygenic scores (PGS), which aggregate genetic liability for disease across the entire genome. While PGS have thus far been extensively explored as clinical and public health tools, the use of PGS in consumer genetic testing has not yet received systematic attention, even though they are already in use for some consumer genetic tests. In this narrative review, we highlight the ethical, legal, and social implications of the use of PGS in DTC genetic tests and synthesize existing solutions to these concerns. We organize these concerns into three domains: (1) industry variation; (2) privacy and commercialization; and (3) patient safety and risk. While previously expressed concerns in these domains will remain relevant, the emergence of PGS-based DTC genetic tests raises challenges that will require novel approaches.