H2O2 is essential for cellular processes and plays a vital role in the regulation of cell signaling pathways, which can be viewed as a warning signal for many kinds of disease including cancer, cardiovascular disease, reproductive abnormalities, diabetes, and renal failure. A H2O2-responsive hydrogel (H2O2-Gel) is a promising candidate for biomedical applications because of its good biocompatibility, similarity to soft biological tissues, ease of preparation, and its ability to respond to H2O2. In this study, the H2O2-responsive moieties used to fabricate H2O2-Gels were reviewed, including thioethers, disulfide bonds, selenides, diselenium bonds, diketones, boronic, and others. Next, the preparation method of H2O2-Gel was divided into two major categories according to their reaction mechanisms: either self-crosslinking or mechanisms entailing the addition of difunctional crosslinkers. Last, the applications of H2O2-Gels were emphasized, which have been viewed as desirable candidates in the fields of drug delivery, the detection of H2O2, glucose-responsive systems, ROS scavengers, tissue engineering, and cell-encapsulation.
Stimuli-responsive luminescent hydrogels (LHs) are of great potential for applications in advanced luminescent sensors; however, structural optimizations and challenges in implementation still remain in their practical applications. Herein, we reported a promising and cooperative strategy to prepare smart LH actuators. Lanthanide(III)-based complexes (LnCs) and sulfur quantum dots (S-QDs) in this contribution are constructed in a cooperative manner; that is, (1) a noncovalent hydrogen bonding model between polyethylene glycol (PEG) in S-QDs and polyurethane (PU) endows LHs with interwoven double networks and improved the mechanical properties and (2) LnCs and S-QDs are two excellent emitting centers with different luminescent excitation properties, leading to the modulating emission colors of LHs by varying the UV irradiation between 254 and 365 nm. Meanwhile, the resultant LHs containing 3.26 wt % of PU possess good mechanical performance and self-healing capability. As a proof of application in stimuli response, our LHs can be served as a ratiometric luminescence probe to electively detect Cu 2+ via exponentially correlating the emission intensity ratio of LnCs and S-QDs to the Cu 2+ concentration. Remarkably, the obtained LHs also show reversible luminescence "On/Off" switch upon alternate exposure to Cu 2+ /glutathione (GSH) under 254 nm, while no obvious luminescent variation is observed under 365 nm.
Objective: To investigate the self-efficacy and mental health of elderly patients with coronary heart disease (CHD) in rural Hebei Province as well as to analyze the relationship between them. Methods: From June 2021 to December 2021, 480 elderly patients with CHD from rural areas, who had been discharged by the Department of Cardiology from three tertiary hospitals in three cities with different economic levels in Hebei Province for more than a year, were selected as the research subjects. The general self-efficacy scale (GSES) and symptom self-rating scale (SCL-90) were used to investigate the self-efficacy and mental health of these patients. SPSS 25.0 was used for data analysis. Results: The total mean self-efficacy score of elderly patients with CHD in rural Hebei Province was 17.18 ± 4.68, which is lower than the international norm (t = -32.067, P = 0.000) and the national norm (t = -28.783, P = 0.000) ; the total average SCL-90 score was 148.64 ± 55.13, which is higher than the national norm for adults and the reference norm for ordinary elderly people; except for hostility and psychosis, the other dimensions were significantly higher than the national norm for adults (P < 0.05); except for psychosis, the other dimensions were significantly higher than the reference norm for ordinary elderly people (P < 0.05); the self-efficacy score was found to be negatively correlated with the total SCL-90 score and the score for each dimension (P < 0.05). Conclusion: Elderly CHD patients with higher self-efficacy in rural Hebei Province have higher mental health level. It is suggested that the mental health of elderly patients with CHD in rural areas can be improved by improving their self-efficacy.
Multiple studies have demonstrated that oral health quality of life (OHQOL) in patients with type 2 diabetes (T2DM) is affected by multiple factors. Therefore, during this study the related factors of OHQOL for T2DM was reviewed, and analyzed them from the aspects of socio-demographic factors, T2DM related factors and oral health related factors. This was to provide basis for nursing workers to develop personalized nursing measures.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.