A Deus, por me amparar sempre nos momentos difíceis, por me dar a força suficiente para vencer todas as dificuldades a serem apresentadas, por me mostrar o caminho nas horas incertas e por me suprir em todas minhas necessidades. Aos meus pais, Pedro Llontop Gonzales e Maria Esther Incio Puyen, pela minha vida, compreensão, esforço, apoio constante, e aos meus irmãos Elvis e Noelia pela ajuda nos momentos que eu precisei, muito agradecido a minha família. À minha orientadora, a Professora Sônia Renaux Wanderley Louro, por sua dedicação, ensinamentos e paciência infinita. Sem ela este trabalho não teria sido realizado. Ao professor Tommaso Del Rosso, do Departamento de Física da PUC-Rio, pela síntese e disponibilização dos nanocompósitos de ouro. Aos meus amigos, em especial meus colegas de laboratório, por me ajudar em todo o trajeto do meu doutorado, sempre me ajudando dentro do laboratório e mediante conhecimentos científicos. A todos os professores da Física pelos conhecimentos recebidos e pela acolhida mostrada.
Incio, Jimmy Llontop; Louro, Sônia Renaux Wanderley (Advisor); Bruno, Antonio Carlos Oliveira (Co-advisor). Functionalization of iron oxide magnetic nanoparticles with hydrophobic drugs and construction of a system for controlled release. Rio de Janeiro, 2014. 100p. MSc.Magnetic nanoparticles have been studied aiming at medical applications, such as treatment of tumors and cancer, for diagnostic purposes and drug delivery.Magnetic nanoparticles can be administered to specific targets and maintained in the proper location by means of an applied magnetic field. For this purpose, nanoparticles with a core of magnetic material are coated with suitable material for functionalization. In this work, we synthesized nanoparticles of iron oxide and functionalized their surface with a bilayer that served as an appropriate compartment for hydrophobic drugs. A promising phthalocyanine derived photosensitizer was solubilized in this compartment. Photosensitizers are molecules that interact with light to form highly reactive species such as singlet oxygen, which destroy cells and surrounding tissues. This process is used in photodynamic therapy (PDT). The generation of singlet oxygen by the phthalocyanine in the hydrophobic compartment was evaluated using the probe 1,3-diphenyl isobenzofuran (DPBF) in formulations with the nonionic surfactants Tween 80 and Pluronic F-127. Aiming to control the release of drugs, we build an electronic circuit to produce an AC magnetic field which acts on the magnetic particles to produce a local temperature increase. This increase in temperature modifies the diffusion of molecules at the surface layer of the nanoparticles, and allows to control the rate of release. Temperature variation produced in the presence of the AC magnetic field was studied. The effect of temperature on the singlet oxygen production was also studied.
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