An 88-year-old woman with a history of chordoma treated by wide local surgery and radiotherapy in 2014 presented to our department with painless nodules growing on her leg of 2 months duration. Physical examination showed 2 dome-shaped, firm, and bluish nodules located on her right leg. No lymph nodes were palpable. DERMATOSCOPIC APPEARANCEDermatoscopic examination revealed arborizing vessels and blue-gray structures. HISTOLOGIC DIAGNOSISThe nodules were excised. Histologic examination revealed lobular proliferation of atypical cells with hyperchromatic cytoplasm and hypertrophic nuclei and the presence of physaliphorous cells in a myxoid stroma. Immunohistochemistry of tumor cells showed positivity for both S-100 protein and pancytokeratin.The medical history, clinical presentation, histopathologic findings, and immunohistochemical profile were consistent with cutaneous metastasis from sacral chordoma.Computed tomography of the whole body and brain was normal. The patient had no clinical or radiologic evidence of relapse or progression 3 months after resection.

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Generalized pustular psoriasis (GPP) occurs rarely in children, it is a chronic inflammatory disorder characterized by the presence of aseptic pustules overlying on erythematous plaques with systemic symptoms such as fever and fatigue. We report the case of a GPP treated with isotretinoin with success. Our case emphasizes that isotretinoin can be considered as a good option in the treatment of pediatric psoriasis because of its short half-life but its effectiveness has not been yet established.

We report the case of an atypical seborrheic keratosis located at the umbilicus with misleading dermoscopy.

Introduction. Prostate cancer is the most common cancer in men. Cutaneous metastasis from prostate cancer is an unusual clinical finding. Scrotal skin metastasis revealing a prostate adenocarcinoma is even rarer. Case Report. We report the case of a 78-year-old patient, who initially consulted for nonspecific scrotal skin lesions evolving for 4 months. Patient’s past history revealed urinary disorders. Physical examination and PSA levels led to perform a prostate biopsy, and the diagnosis of prostate adenocarcinoma was made. Bone scintigraphy showed that the cancer has spread to the bones. Imaging studies showed that the cutaneous lesions were limited to the scrotal wall. Cutaneous metastasis was suspected and was proven on skin biopsy. The patient received second-generation hormone therapy with good clinical and biological outcomes. Discussion. Based on literature review of nearly 2,500 skin metastases, we found that only 436 were spreading from the genitourinary tract. Skin metastasis from prostate adenocarcinoma is a rare entity with a low incidence rate (0.36%). Conclusion. Skin metastases, and especially in the scrotum, are exceptional in prostate cancer. However, in any patient with a prostate adenocarcinoma, nonspecific cutaneous lesions should lead to perform skin biopsy in order to identify and initiate treatment of cutaneous metastases.

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