A novel non-enzymatic electrochemical sensor for highly sensitive and selective detection of dopamine was developed based on a 3,4,9,10-perylene tetracarboxylic acid functionalized graphene-multiwalled carbon nanotube-gold nanoparticle nanocomposite modified glassy carbon electrode (PTCA-RGO-MWCNTs-Au NPs/GCE). The nanocomposite film was prepared by a facile, eco-friendly and controllable route and its morphology was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopic (EDX) analysis, and X-ray diffraction (XRD) spectroscopy, respectively. Cyclic voltammetry and chronoamperometry were used for evaluating the electrochemical behaviors of the prepared sensor. The DA sensor exhibited excellent electrochemical performance toward DA with a sensitivity as high as 0.124 μA mM-1, a wide linear range of 1-100 μM and a low detection limit of 0.07 μM (S/N = 3). Moreover, it showed good selectivity toward DA without any obvious interference by AA and UA. Furthermore, the prepared DA sensor was applied to detect DA in real samples with satisfactory results.
The use of graphene has leapt forward the materials field and the functional modification of graphene has not stopped. In this work, β-lactoglobulin (BLG) was used to functionalize reduced graphene oxide (RGO) based on its amphiphilic properties. Also, trimetallic PtAuPd nanoparticles were reduced to the surface of BLG-functionalized RGO and formed BLG-PtAuPd-RGO nanocomposite using facile synthesis. Transmission electron microscopy, energy-dispersive X-ray spectroscopy and Fourier transform infrared spectra were used to characterize the nanocomposite. Electrocatalytic analysis was evaluated through cyclic voltammetry and chronoamperometry methods. We developed a glucose sensor by fabricating GOD-BLG-PtAuPd-RGO/glassy carbon (GC) electrode. It presented a remarkable sensitivity of 63.29 μA mM−1 cm−2 (4.43 μA mM−1), a wider linear range from 0.005 to 9 mM and a lower detection limit of 0.13 μM (S/N = 3). Additionally, the glucose sensor exhibited excellent testing capability in human serum samples.
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