The NH3 uniformity and conversion rate produced by the urea–water solution spray system is an essential factor affecting de-NOx efficiency. In this work, a three-dimensional simulation model was developed with the CFD software and was employed to investigate the effects of two typical injection methods (wall injection and center injection) and three distribution strategies (pre-mixer, post-mixer, pre-mixer, and post-mixer) of two typical mixers on the urea conversion rate and uniformity. The field synergy principle was employed to analyze the heat transfer of different mixer flow fields. The results show that the single mixer has instability in optimizing different injection positions due to different injection methods and injection positions. The dual-mixer is stable in the optimization of the flow field under different conditions. The conclusion of the field synergy theory of the single mixer accords with the simulation result. The Fc of the dual-mixer cases is low, but the NH3 conversion and uniformity index rate are also improved due to the increase in the residence time of UWS.
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