We show how to generate tripartite entanglement in a cavity magnomechanical system which consists of magnons, cavity microwave photons, and phonons. The magnons are embodied by a collective motion of a large number of spins in a macroscopic ferrimagnet, and are driven directly by an electromagnetic field. The cavity photons and magnons are coupled via magnetic dipole interaction, and the magnons and phonons are coupled via magnetostrictive (radiation pressure-like) interaction. We show optimal parameter regimes for achieving the tripartite entanglement where magnons, cavity photons, and phonons are entangled with each other, and we further prove that the steady state of the system is a genuinely tripartite entangled state. The entanglement is robust against temperature. Our results indicate that cavity magnomechanical systems could provide a promising platform for the study of macroscopic quantum phenomena.

A pathogen may cause infected plants to promote the performance of its transmitting vector, which accelerates the spread of the pathogen. This positive effect of a pathogen on its vector via their shared host plant is termed indirect mutualism. For example, terpene biosynthesis is suppressed in begomovirus-infected plants, leading to reduced plant resistance and enhanced performance of the whiteflies (Bemisia tabaci) that transmit these viruses. Although begomovirus-whitefly mutualism has been known, the underlying mechanism is still elusive. Here, we identified bC1 of Tomato yellow leaf curl China virus, a monopartite begomovirus, as the viral genetic factor that suppresses plant terpene biosynthesis. bC1 directly interacts with the basic helix-loop-helix transcription factor MYC2 to compromise the activation of MYC2-regulated terpene synthase genes, thereby reducing whitefly resistance. MYC2 associates with the bipartite begomoviral protein BV1, suggesting that MYC2 is an evolutionarily conserved target of begomoviruses for the suppression of terpene-based resistance and the promotion of vector performance. Our findings describe how this viral pathogen regulates host plant metabolism to establish mutualism with its insect vector.

SUMMARY Signaling via the Akt serine/threonine protein kinase plays critical roles in the self-renewal of embryonic stem cells and their malignant counterpart, embryonal carcinoma cells (ECCs). Here we show that in ECCs, Akt phosphorylated the master pluripotency factor Oct4 at threonine 235, and that the levels of phosphorylated Oct4 in ECCs correlated with resistance to apoptosis and tumorigenic potential. Phosphorylation of Oct4 increased its stability, and facilitated its nuclear localization and its interaction with Sox2, which promoted the transcription of the core stemness genes POU5F1 and NANOG. Furthermore, in ECCs, unphosphorylated Oct4 bound to the AKT1 promoter and repressed its transcription. Phosphorylation of Oct4 by Akt resulted in dissociation of Oct4 from the AKT1 promoter, which activated AKT1 transcription and promoted cell survival. Therefore, a site-specific, post-translational modification of the Oct4 protein orchestrates the regulation of its stability, subcellular localization and transcriptional activities, which collectively promotes the survival and tumorigenicity of ECCs.

We show how to create quantum squeezed states of magnons and phonons in a cavity magnomechanical system. The magnons are embodied by a collective motion of a large number of spins in a macroscopic ferrimagnet, and couple to cavity microwave photons and phonons (vibrational modes of the ferrimagnet) via the magnetic dipole interaction and magnetostrictive interaction, respectively. The cavity is driven by a weak squeezed vacuum field generated by a flux-driven Josephson parametric amplifier, which is essential to get squeezed states of the magnons and phonons. We show that the magnons can be prepared in a squeezed state via the cavity-magnon beamsplitter interaction, and by further driving the magnon mode with a strong red-detuned microwave field, the phonons are squeezed. We show optimal parameter regimes for obtaining large squeezing of the magnons and phonons, which are robust against temperature and could be realized with experimentally reachable parameters.