Objective. Currently, the field of low-dose CT (LDCT) denoising is dominated by supervised learning based methods, which need perfectly registered pairs of LDCT and its corresponding clean reference image (normal-dose CT). However, training without clean labels is more practically feasible and significant, since it is clinically impossible to acquire a large amount of these paired samples. In this paper, a self-supervised denoising method is proposed for LDCT imaging. Approach. The proposed method does not require any clean images. In addition, the perceptual loss is used to achieve data consistency in feature domain during the denoising process. Attention blocks used in decoding phase can help further improve the image quality. Main results. In the experiments, we validate the effectiveness of our proposed self-supervised framework and compare our method with several state-of-the-art supervised and unsupervised methods. The results show that our proposed model achieves competitive performance in both qualitative and quantitative aspects to other methods. Significance. Our framework can be directly applied to most denoising scenarios without collecting pairs of training data, which is more flexible for real clinical scenario.
In our research, the complete mitochondrial genome of Culicicapa ceylonensise was determined and described, which was the first complete mitogenome reported in the Culicicapa. The complete mitochondrial genome sequence of C. ceylonensise was 16,851 bp in length and contains 13 protein-coding genes (PCGs), two ribosomal RNA (rRNA) genes, 22 transfer RNA (tRNA) genes, and one control region (D-loop). The overall base composition of the mitochondrial DNA was 29.8% for A, 23.5% for T, 31.8% for C, and 14.9% for G, and the percentage of GC content was 46.7%. The complete mitochondrial genome information of C. ceylonensis will contribute to the phylogenetic studies of the Passeriformes.
Horornis fortipes has been listed on the IUCN red list of endangered species -Least Concern (LC). In this study, we sequenced the complete mitochondrial genome of H. fortipes by the polymerase chain reaction (PCR) method. The complete mitochondrial genome of H. fortipes is a circular molecule of 16,908 bp in total length, and it contains 13 typical vertebrate protein-coding genes, 22 transfer RNA genes, 2 ribosomal RNA genes (12srRNA, 16srRNA), and 2 control regions. This is the fist complete mitochondrial genome reported in Cettiidae. Phylogenetic analysis showed that Cettiidae diverged earlier than other family except Pycnonotidae, Acrocephalidae, and Pnoepygidae among 15 families within Passeriformes.
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