An atom and step economy cascade trifluoromethylation/cyclization of unactivated alkene with Langlois reagent as a CF 3 source is described. A variety of polycyclic quinazolinones were successfully synthesized in 52-81% yields under transition metal-and oxidant-free conditions. The Langlois reagent used in this strategy as a CF 3 reagent possesses the advantages of bench-stablity, cost-effectivity and high-efficiency. Additionally, gram-scale reaction, broad substrate scope and good functional group tolerance demonstrated the synthetic usefulness of this protocol.

Organosulfurs are important commodity chemicals and indispensable synthetic intermediates in modern chemistry that traditionally synthesized using metal catalysts, oxidants or strong bases, which caused numerous issues of environment pollutions. The...

A series of chiral ferrocene-backbone phosphines-spiro phosphonamidite ligands was developed for ruthenium-catalyzed enantioselective access to a broad range of β-amino alcohols from 1,2-diols and amines via the borrowing-hydrogen prciniple.

The first example of manganese catalyzed asymmetric hydrogenation of β-keto sulfones for the construction of chiral β-hydroxy sulfones with up to 97% yield and 97% ee.

The iridium/f-diaphos catalyzed asymmetric hydrogenation of 2-imidazolyl aryl or alkyl ketones to afford the desired chiral alcohols was realized with moderate to excellent enantioselectivities.