Transition metal phosphides are considered as ideal alternatives for noble metal catalysts for hydrogen evolution reactions. In this study, amorphous NiCuFeP nanosheets are uniformly coated on self-supporting Cu3P nanowire array...
Enhancer deregulation is a well-established pro-tumorigenic mechanism but whether it plays a regulatory role in tumor immunity is largely unknown. Here, we demonstrate that tumor cell ablation of mixed-lineage leukemia 3 and 4 (MLL3 and MLL4, also known as KMT2C and KMT2D, respectively), two enhancer-associated histone H3 lysine 4 (H3K4) mono-methyltransferases, increases tumor immunogenicity and promotes anti-tumor T cell response. Mechanistically, MLL4 ablation attenuates the expression of RNA-induced silencing complex (RISC) and DNA methyltransferases through decommissioning enhancers/super-enhancers, which consequently lead to transcriptional reactivation of the double-stranded RNA (dsRNA)-interferon response and gasdermin D (GSDMD)-mediated pyroptosis, respectively. More importantly, we reveal that both the dsRNA-interferon signaling and GSDMD-mediated pyroptosis are of critical importance to the increased anti-tumor immunity and improved immunotherapeutic efficacy in MLL4-ablated tumors. Thus, our findings establish tumor cell enhancers as an additional layer of immune evasion mechanisms and suggest the potential of targeting enhancers or their upstream and/or downstream molecular pathways to overcome immunotherapeutic resistance in cancer patients.
Regulating the crystal plane exposure of catalysts is an effective way for enhancing their oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) activities. Herein, we synthesize ultrathin metal phosphide...
The heterostructure of Ni3S4–MoS2 as an efficient hydrogen evolution catalyst was fabricated by a one-pot hydrothermal method. The as-synthesized catalyst with interfacial electron redistribution generated numerous active sites.
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