Blueberry juice has been found to undergo severe browning after treatment and cold storage, such as processing by high hydrostatic pressure (HHP) at 550 MPa/10 min/25°C followed storage at 4°C for 4 days. This browning may be due to the degradation of anthocyanin (AC) in the berries. Therefore, in this study, gallic acid (GA), ferulic acid (FA), ascorbic acid (VC), citric acid (CA), tea polyphenol (TP) and α-tocopherol (VE) were compared to determine their ability to improve the stability of the AC in HHP-treated blueberry juice. The juice was combined with the six abovementioned antioxidants at different concentrations, then treated by HHP at 550 MPa/10 min/25°C and stored at 4°C for 20 days. Thereafter, the pH levels, degrees °Brix (°Bx), color parameters, total AC content and polyphenol oxidase (PPO) activity of the blueberry juice blend were measured and compared. Gallic acid at 2 g/L was found to be the most effective antioxidant to protect against AC degradation. After storage at 4°C for 20 days, the AC content of the juice with no added antioxidants had decreased by 62.27% with a PPO relative activity of 50.78%, while the AC content of juice supplemented with 2 g/L GA had decreased by 13.42% with a PPO relative activity of 28.13%. The results of this study, thus, suggest that GA can stabilize the structure of AC in blueberry juice and reduce PPO activity, which may be beneficial in guiding the production of blueberry juice with high AC retention.
Intracerebral hemorrhage (ICH) is a common neurosurgical emergency in high mortality. In recent years, stereotactic aspiration and subsequent fibrinolysis has been considered less invasive and more effective compared with the conventional surgical removal of ICH. On this basis, we improved the treatment method and combined it with the mature prone position therapy in ICU. We present two unique cases of intraventricular hemorrhage treated by prone position, radiographic evidence proves its availability and feasibility. Prone positin can liquefy hematoma better, make its density more uniform thus easy to drain. In similar cases of intraventricular hemorrhage, we hypothesize that prone position may offer a greater result of drainage, and should be strongly recommended for treatment.
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