Summary Correlation analysis is both popular and useful in a number of social networking research, particularly in the exploratory data analysis. In this paper, three well‐known and often‐used correlation coefficients, Pearson product–moment correlation coefficient, Spearman, and Kendall rank correlation coefficients, are compared from definition to application domain. Based on the characteristics of the pump's vibration dataset, the nonparametric and distribution‐free Spearman rank correlation coefficient is introduced to analyze the relationship between the pump's working state and each of the 207′880 variables. The percentage of variables and exact variables' tables with high Spearman's correlation coefficients for states I and II, states I and III, states II and III, and three states in different files are obtained respectively, which has important valuation for the future research of the unsupervised machine learning system. Copyright © 2015 John Wiley & Sons, Ltd.
In recent decades, 3D reconstruction techniques have been applied in an increasing number of areas such as virtual reality, robot navigation, medical imaging and architectural restoration of cultural relics. Most of the inspection techniques used in railway systems are, however, still implemented on a 2D basis. This is particularly true of track inspection due to its linear nature. Benefiting from the development of sensor technology and constantly improving processors, higher quality 3D model reconstructions are becoming possible which push the technology into more challenging areas. One such advancement is the use of 3D perceptual techniques in railway systems. This paper presents a novel 3D perceptual system, based on a low-cost 2D laser sensor, which has been developed for the detection and characterisation of physical surface defects in railway tracks. An innovative prototype system has been developed to capture and correlate the laser scan data; dedicated 3D data processing procedures have then been developed in the form of three specific defect-detection algorithms (depth gradient, face normal and face-normal gradient) which are applied to the 3D model. The system has been tested with rail samples in the laboratory and at the Long Marston Railway Test Track. The 3D models developed represent the external surface of the samples both laterally (2D slices) and longitudinally (3D model), and common surface defects can be detected and represented in 3D. The results demonstrate the feasibility of applying 3D reconstruction-based inspection techniques to railway systems.
Aged skin wounds heal poorly, resulting in medical, economic, and social burdens posed by nonhealing wounds. Age-related defects in repair are associated with reduced myofibroblasts and dysfunctional extracellular matrix (ECM) deposition. Bidirectional cell-cell communication involving exosome-borne cargo such as micro RNAs (miRs) has emerged as a critical mechanism for wound healing and aged tissue regeneration. Here we report that at the wound edge, aged fibroblasts display reduced migration and differentiation into myofibroblasts, with impaired ECM deposition, when compared with young tissue. Proper activation of fibroblasts to myofibroblasts may alleviate age-related defects in wound healing. Herein, an exosome-guided cell technique was performed to induce effective wound healing. Supplementing wounds with exosomes isolated from young mouse wound-edge fibroblasts (exosomesYoung) significantly improved the abundance of myofibroblasts and wound healing in aged mice and caused fibroblasts to migrate and transition to myofibroblasts in vitro. To determine the underlying mechanism, we found that exosomal transfer of miR-125b to fibroblasts inhibited sirtuin 7 (Sirt7), thus accelerating myofibroblast differentiation and wound healing in aged mice. Notably, after epidermal inhibition of miR-125b or overexpression of Sirt7 in fibroblasts, migration and myofibroblast transition were perturbed. Our findings thus reveal that miR-125b is transferred through exosomes from young fibroblasts to old fibroblasts contributes to promoting fibroblast migration and transition to counteract aging, suggesting a potential avenue for anti-aging interventions in wound healing. Graphical Abstract
H5N1 highly pathogenic avian influenza (HPAI) was one of the most important avian diseases in poultry production of China, especially in Guangdong province. In recent years, new H5N1 highly pathogenic avian influenza viruses (HPAIV) still emerged constantly, although all poultry in China were immunized with H5N1 vaccinations compulsorily. To better understand the pathogenicity and transmission of dominant clades of the H5N1 HPAIVs in chicken from Guangdong in 2012, we chose a clade 7.2 avian influenza virus named A/Chicken/China/G2/2012(H5N1) (G2) and a clade 2.3.2.1 avian influenza virus named A/Duck/China/G3/2012(H5N1) (G3) in our study. Our results showed that the chickens inoculated with 103 EID50 of G2 or G3 viruses all died, and the titers of virus replication detected in several visceral organs were high but different. In the naive contact groups, virus shedding was not detected in G2 group and all chickens survived, but virus shedding was detected in G3 group and all chickens died. These results showed that the two clades of H5N1 HPAIVs had high pathogenicity in chickens and the contact transmission of them was different in chickens. The results of cross reactive HI assay showed that antigens of G2 and G3 were very different from those of current commercial vaccines isolates (Re-4, Re-6, and D7). And to evaluate the protective efficacy of three vaccines against most isolates form Guangdong belonging to clade 2.3.2.1 in 2012, G3 was chosen to challenge the three vaccines such as Re-4, Re-6, and D7. First, chickens were immunized with 0.3 ml Re-4, Re-6, and D7 inactivated vaccines by intramuscular injection, respectively, and then challenged with 106 EID50 of G3 on day 28 post-vaccination. The D7 vaccine had 100% protection against G3 for chickens, the Re-6 vaccine had 88.9%, and the Re-4 vaccine only had 66.7%. Our results suggested that the D7 vaccine could prevent and control H5N1 virus outbreaks more effectively in Guangdong. From the above, it was necessary to conduct continuously epidemiological survey and study the pathogenicity and antigenic variation of avian influenza in Southern China.
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