A practical palladium and amino acid
co-catalyzed hydroarylation
of unbiased alkenes has been developed. Using the transient-directing
strategy, this chemistry could construct isolated chiral Csp2–Csp3 bonds with good regio- and enantioselectivity.
The potential synthetic utility of a representative product was well-illustrated
by further transformations. Furthermore, the mechanism of this reaction
was intensively studied through control experiments and DFT calculations.
An one-pot tandem dehydration/1,6-addition/decarboxylation transformation of β-keto acids and 4-hydroxybenzyl alcohols provides an metal-free protocol to chiral β,β-diaryl ketones.
A novel and practical method to synthesize trifluoromethyl tertiary alcohols has been developed. Under mild reaction conditions, the present reaction could be compatible with a wide range of functional groups. Moreover, the performance of gram-scale reaction and further transformations illustrated the good potential utility of the present chemistry. Furthermore, the radical process of this reaction has been proved by mechanistic studies.
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