A novel approach for the visible-light-initiated
synthesis of 2-amino-4H-pyran-3,5-dicarbonitrile
derivatives via a one-pot, three-component
reaction of aldehydes or isatins, malononitrile, and α-cyano
ketones has been developed. The reaction was carried out at room temperature
in ethanol/water to give the corresponding products with a wide range
of functional groups in high yields. This process did not require
any additives or chromatographic separation and could be applied for
gram-scale synthesis.
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