A visible-light-induced highly practical catalyst-free Wolff rearrangement/domino [4 + 2] cycloaddition of 2benzothiazolimines with α-diazo ketones has been developed. This protocol provides a concise and facile synthetic approach to construct a broad range of benzothiazolopyr-imidine derivatives bearing a quaternary carbon center under mild reaction conditions with high isolated yields and excellent diastereoselectivities (up to > 99% yield and > 20 : 1 d.r.).
Herein, an NHC (N-heterocyclic carbene)-catalyzed radical coupling reaction between aldehydes and azobis-(isobutyronitrile) (AIBN) has been developed. This method provides an efficient and convenient approach for the synthesis of β-ketonitriles containing a quaternary carbon center (31 examples, up to >99% yield) utilizing commercially available substrates. This protocol features broad substrate scope, good functional group tolerance, and high efficiency under metal-free and mild reaction conditions.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.