Background Sinupret drops is commonly used as agent dissolving nasal secretions. However, there is no specific regime of Sinupret drops for pediatric patients in China. Therefore, we investigate its current medication in Chinese pediatric patients to provide a recommendation of safe drug use.Methods We collect 6,893 outpatient and emergency pediatric prescriptions of Sinupret drops (age ≤ 15) and focused on the analysis of practical drug dosage and potential risks.Results One-half of the adult dosage was mainly chosen for out-patient children, while the full adult dosage was much more used for pediatric patients in emergency. Its usage in low-age pediatric patients requires further evaluation and surveillance. The pharmaceutical reaction of ethanol in Sinupret drops with some cephalosporins during drug taking will lead to unexpected drug reactions.Conclusion To prevent potential side effects, treatment with Sinupret drops as an adjunct for pediatric patients should draw more attention from their doctors and pharmacists. The age and weight of pediatric patients need to be considered as important parameters for drug administration of Sinupret drops. It is important to strengthen the education of medication, and much attention should be paid to the interval of drug administration.
What is known and objective: Adverse drug reaction (ADR) reporting is generally of poor quality, which may delay post-marketing regulatory actions. Here, we evaluated the quality of ADR reporting at our institution and examined the roles of clinical pharmacists in this process.Methods: We retrospectively reviewed ADR reports at our hospital between 2017 and 2019 to assess the number, source, drugs, and routes of administration. The quality assessment of ADR case reports form issued by the China Adverse Drug Reaction Monitoring Centre was used to assess the quality of ADR reports. Quality scores of ADR reports from pharmacists and nonpharmacists were assessed before and after review by clinical pharmacists.
We undertook this survey about the use of clarithromycin in the Ear, Nose, and Throat (ENT) Outpatient Department of Fudan University Hospital to understand its utilization patterns and rational use. A survey of prescriptions given to outpatients was carried out, and detailed information of the patients, including age, sex, diagnosis, combined medication, and other information, was recorded in Excel spreadsheets. The rationale for each prescription was evaluated retrospectively. Based on our analysis, 82.5% of the clarithromycin prescriptions were for the treatment of rhinosinusitis. It was found that the parameters for the diagnosis of this condition were surprisingly broad and should have been more specific. In addition, the clarithromycin dosage regimen varied in clinical practice. For chronic rhinosinusitis, the duration of treatment was between 8 and 16 days, which was not sufficient. Moreover, clarithromycin was prescribed along with considerable numbers of pharmacotherapeutic anti-allergic drugs. Our survey indicated that improvements in the quality of clarithromycin prescriptions in otolaryngology outpatients should be made. Furthermore, the importance of medical education to patients should be emphasized. In addition, the interaction between clarithromycin and other anti-allergic drugs requires further investigation.
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