Improving the solubility of poorly soluble drug has always been a challenging subject in the field of medicine. In this regard, the pharmaceutical cocrystal strategy has been considered an effective...
In
this study, the crystal structures of 1:1 theophylline–ferulic
acid cocrystal polymorphs are reported for the first time. Interestingly,
both forms crystallize in the same space group but with a different
number of molecules in the asymmetric unit (form I = 2; form II =
4). The two polymorphs show distinct crystal morphology, demonstrating
prism and rod single crystals, respectively. Theoretical calculations
are performed to predict their morphology and thermodynamic stability
(form I > form II). The prediction result agrees well with the
measured
pharmaceutical properties. Form I presents better hygroscopic stability
(RH < 95%), slower dissolution, and lower solubility (1.06 ±
0.03, 1.63 ± 0.01, 1.30 ± 0.08 and 4.09 ± 0.05 mg/mL
in water, pH = 1.2, pH = 4.5 and pH = 6.8 buffered solutions) over
form II (8.45 ± 0.33, 2.41 ± 0.17, 3.46 ± 0.26 and
28.71 ± 0.87 mg/mL in water, pH = 1.2, pH = 4.5 and pH = 6.8
buffered solutions). In summary, this work elucidates the experimental
findings with relevant predictions systematically and enriches our
understanding of the structure–property relationship of the
theophylline cocrystal system.
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