Precise alignment of the system scan geometry is crucial to ensure the reconstructed image quality in the cone-beam CT system. A calibration method that depends on the local feature of ball bearings phantom and point-like markers is probably affected by local image variations. Besides, multiple projections with circular scanning are usually required by this type of method to derive misaligned parameters. In contrast to previous works, this paper proposes a method that depends on the global symmetric low-rank feature of a novel phantom, which can accurately represent the system geometrical misalignment. All the misaligned parameters of the cone-beam CT system can be estimated from a single perspective direction without circular scanning. Meanwhile, since the global low-rank feature of the phantom is utilized, the proposed method is robust to the noise. Extensive simulations and real experiments validate the accuracy and robustness of our method, which achieves better performance compared to an existing phantom-based method.
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