Background: Amnestic mild cognitive impairment (aMCI) is considered to be a transitional stage of Alzheimer’s disease (AD) because it has the same clinical symptoms as AD but with lower severity. Studies have confirmed that patients with aMCI are more likely to develop to AD. Although studies on resting state functional connectivity have revealed the abnormal organization of brain networks, the dynamic changes of the functional connectivity across the scans have been ignored. Objective: Dynamic functional connectivity is a novel method to reveal the temporal variation of brain networks. This paper aimed to investigate the dynamic characteristics of brain functional connectivity in the early and late phases of aMCI. Methods: Based on the “triple network” model, we used the sliding time window approach to construct dynamical functional networks and then analyzed the dynamic characteristics of the functional connectivity across the entire scan. Results: The results showed that patients with aMCI had longer dwell times in weaker network connection than in the strong network. The transitions between different states become more frequent, and the stability of the patient’s brain core network deteriorates. This study also found the correlation between the altered dynamic properties of the core functional networks and the patient’s clinical Mini-Mental State Examination assessment scale sores. Conclusion: This study revealed that the characteristics of dynamic functional networks constructed by the core cognitive networks varied in distinct ways at different stages of aMCI, which could provide a new idea for exploring the neuro-mechanisms of neurological disorders.
Retirement planning fulfillment is necessary for older adults to adapt to later life and maintain their quality of life. This study investigates the internal mechanisms between retirement planning fulfillment and positive mental health among older adults. 1200 Chinese older adults (Mage = 68.49, SD = 7.27; 57% female) completed a questionnaire package measuring retirement planning fulfillment, positive mental health, post-retirement social activities, and self-esteem. Results indicated that older adults in rural areas had significantly lower retirement planning fulfillment than those in urban areas. Retirement planning fulfillment was positively associated with social activity, self-esteem, and positive mental health. Social activities and self-esteem mediated the relationship between retirement planning fulfillment and positive mental health. This study suggests the need for further investigation of retirement planning fulfillment, which helps improve older adults’ ability to cope with later life.
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