No abstract

This review summarizes the isolation, chemical identification, and biochemical activities of Camellia triterpenoid saponins, updating a previous review and encompassing all new studies through September 2017. Further, molecular simulations of the interaction between several known cytotoxic oleiferasaponin monomers and Interleukin-6 are discussed, demonstrating that molecular modeling is a convenient method to obtain structure-activity information.

Hyperprins A (1) and B (2), two polyprenylated acylphloroglucinol related meroterpenoids with undescribed carbon skeletons, were isolated from Hypericum przewalskii. Compound 1 possesses a new 6/6/6/6/5/5 hexacyclic system with an unprecedented tetracyclo[10.3.1.0 3,8 .0 8,12 ]hexadecane motif. Compound 2 features a unique 6/8/6/6 tetracyclic scaffold. Their structures were determined by spectroscopic data, chemical method, and X-ray crystallography. Compound 1 showed antiproliferation activity against the MV-4-11 cell line, and the p-bromobenzoate derivative of 2 displayed PTP1B inhibition. https://pubs.acs.org/doi/10.1021/acs.orglett.0c00786.Experimental section; X-ray crystallographic data for 1 and 3; and spectroscopic data (MS, NMR, UV, ECD, and IR spectra) of 1−3 (PDF)Accession Codes CCDC 1903206 and 1908932 contain the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk