Since the beginning, Contract Research
Organizations (CROs) have always faced two core challenges: low profit
margin and limited market capitalization. Nowadays, the CRO industry
is experiencing a supply chain disruption, driving it to chase the
upstream part of the pharmaceutical value chain. A 3P (past, present,
prospect) decision-tree model is developed, revealing the future of
the CRO industry may be a CRO-Venture model. Perspectives on the potential
transformation of CRO industry will contribute to the real-world practice
and innovation of this business model.
As a business model, drug repositioning
is facing increasing challenges
from both academia and industry. To examine the feasibility of drug
repositioning as a systematical business model, a drug revenue formula
is introduced. By breaking down key factors into indication, price,
patient population, and market share, the potentiality of the drug
repositioing business model is confirmed. In addition, some unworkable
repositioning stratgies are also summarized.
Contributions from traditional knowledge and history have proven useful in recent years to advance drug discovery. In response to the emergence of covid-19, scientists revisited traditional Chinese medicine. This source of inspiration for drugs to treat this new disease is described here at three different levels: traditional Chinese medicinal herbs, traditional Chinese medical formulas, and traditional Chinese medical texts. Drug discovery inspired by traditional Chinese medicine still faces serious resistance for various reasons, including its system of formulas and clinical trial design. A perspective that includes related issues would benefit the reasonable application of traditional knowledge in drug research and development.
Written in Dunhuang, Chiwu shenzhen jing (赤烏神針經) is a long lost medical work and its contents remain unknown. Based on Dunhuang manuscripts and Japanese collections of ancient Chinese medical classics, this research argues that Chiwu shenzhen jing concerns temporally sensitive needling treatment, which forms an early practice of the midnight-noon ebb-flow (the commonly-used translation of Ziwu liuzhu 子 午流注) therapy, in fact, as early as the 3rd century CE. At the very end of this article, this research emphasizes the role of Dunhuang as a vehicle for promoting the ebb-flow theory through the Sino-Indian medical exchanges.
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