-The adult mammalian heart has limited ability to repair itself following injury. Zebrafish, newts and neonatal mice can regenerate cardiac tissue, largely by cardiac myocyte (CM) proliferation. It is unknown if hearts of young large mammals can regenerate. -We examined the regenerative capacity of the pig heart in neonatal animals (ages: 2, 3 or 14 days postnatal) after myocardial infarction (MI) or sham procedure. Myocardial scar and left ventricular function were determined by cardiac magnetic resonance (CMR) imaging and echocardiography. Bromodeoxyuridine pulse-chase labeling, histology, immunohistochemistry and Western blotting were performed to study cell proliferation, sarcomere dynamics and cytokinesis and to quantify myocardial fibrosis. RNA-sequencing was also performed. -After MI, there was early and sustained recovery of cardiac function and wall thickness in the absence of fibrosis in 2-day old pigs. In contrast, older animals developed full-thickness myocardial scarring, thinned walls and did not recover function. Genome wide analyses of the infarct zone revealed a strong transcriptional signature of fibrosis in 14-day old animals that was absent in 2-day old pigs, which instead had enrichment for cytokinesis genes. In regenerating hearts of the younger animals, up to 10% of CMs in the border zone of the MI showed evidence of DNA replication that was associated with markers of myocyte division and sarcomere disassembly. -Hearts of large mammals have regenerative capacity, likely driven by cardiac myocyte division, but this potential is lost immediately after birth.
This paper briefly introduces the water transfer printing craft's basic concepts and characteristics, water transfer printing technology classification, material that water transfer printing technology uses , water transfer printing process of applications and the analysis of water transfer printing technology application prospect .
The ergonomics research of the joystick in excavator cab is a problem which requires immediately solution in our country. In this paper, we come to a conclusion that the improved cab takes shorter time and less muscle activity than the previous cab which means that the improved cab have advantage to the previous one in comfort and work efficiency.
Industrial design is a design practical activity based on innovation. TRIZ is a method and tool about systematic innovation. The invention principles of TRIZ are suitable for finding a new path of industrial design. This paper analyses the basic principle of TRIZ theory, and discusses the application of the principle of TRIZ in industrial design field. On the basis of the theory of TRIZ, two new products are designed. The corresponding result shows the combination of industrial design and innovation methods will promote industrial design.
With the author and others scientific investigation on China Wenchuan Ms8.0 earthquake, China Yushu Ms7.1 earthquake and "China's active fault surveying and earthquake hazard evaluation project" relevant data results and the world requirements about project setback of active faults, etc., this paper concluded that: (1) width of Surface-Fault-Rupture is about 40m by statistics, or from the main surface rupture trace about 20m; (2) width of Surface-Fault-Rupture S and the fault vertical offset V, statistical diagrams and formulas S=8.72+9.01V; (3) Setback of the main surface trace D and buildings from damage index I, statistical diagrams and formulas I=0.7969-0.00231D; (4) based on the first three results and by the actual statistics of accuracy, we get three active fault location accuracy level of the standard i, ii, iii, respectively, the error is ± 5m, ± 25m, ± 60m, also, can give this level of standards of Surface-Fault-Rupture width to the actual engineering applications.
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