Infrared thermal imaging technology was used to observe the changes in infrared radiation temperature at acupoints in rats caused by chronic myocardial ischemia injury. background: When diseases occur in the viscera of the human body, the body surface will react. For example, patients with coronary heart disease and angina pectoris may experience pain at the back of the sternum, which can often radiate to the precordial area and the left upper limb; Medical infrared thermal imaging technology can detect the decrease of temperature in the precordial area of coronary heart disease. Similarly, acupoints, located on the body surface, are the action points of acupuncture and moxibustion treatment, and are also considered to be related to the viscera state. When diseases occur in the viscera, will acupoints also show something? If the acupoints can reflect the changes of viscera, will the detection and attention to acupoint pain or temperature changes be helpful for future disease diagnosis? This is an interesting question. Objective: This study aims to compare the difference of body surface infrared radiation temperature information of three groups of acupoints: bilateral Neiguan (PC6), bilateral Yanglingquan (GB33), and bilateral Sham Acupoints (SA) in the pathological state of myocardial ischemia injury, and to explore the relationship between acupoints and viscera state. objective: Infrared thermal imaging technology was used to observe the changes of infrared radiation temperature at acupoints in rats caused by chronic myocardial ischemia injury. Compare the body surface infrared radiation information difference between bilateral Neiguan (PC6), bilateral Yanglingquan (GB33) and bilateral Sham Acpoints (SA) in physiological and myocardial ischemia injury, and explore the connection between acupoints and visceral state. Methods: SPF adult Wistar male rats (n = 20) were randomly divided into a control (CTL; n = 10) and an isoproterenol group (ISO; n = 10). Chronic myocardial injury was induced in rats by subcutaneous injection of isoproterenol hydrochloride for 14 d. On the second day after the establishment of the model, the serum levels of cardiac troponin (cTnT) and creatine kinase isoenzyme (CK-MB) were measured by enzyme-linked immunosorbent assay (ELISA) and ELISA-like assays with aptamers (ELASA). The morphological changes of the myocardial tissue in the two groups were observed by hematoxylin-eosin (HE) staining and their pathological scores were evaluated, which was then used to determine the myocardial ischemic injury. Two days before and after the establishment of the model, the electrocardiograms (EGC) of the two groups of rats were recorded by the ECG data acquisition system, and the infrared thermal imaging platform was used to detect the temperature of the six acupoints. method: SPF adult Wistar male rats (n = 20) were randomly divided into control (CTL; n = 10) and isoproterenol group (ISO; n = 10). Chronic myocardial injury was induced in rats by subcutaneous injection of isoproterenol hydrochloride for 14 d. On the second day after the establishment of the model, the serum levels of cardiac troponin (cTnT) and creatine kinase isoenzyme (CK-MB) were measured by enzyme-linked immunosorbent assay (ELISA) and ELISA-like assays with aptamers (ELASA). The morphological changes of the myocardial tissue in the two groups were observed by hematoxylin-eosin (HE) staining and their pathological scores were evaluated, which was then used to determine the myocardial ischemic injury. Two days before and after the establishment of the model, the electrocardiograms (EGC) of the two groups of rats were recorded by the ECG data acquisition system, and the infrared thermal imaging platform was used to detect the temperature of the six acupoints. Results: 1. After subcutaneous injection of isoproterenol hydrochloride for 14 days, the ST segment of the ECG decreased in the ISO group compared with that of the CTL group; 2. Myocardial tissue injury was serious in the ISO group compared to the CTL group; 3. Serum cTnT and CK-MB were significantly increased (P <0 01) in the ISO group, compared to that in the CTL group; 4. The infrared radiation temperature on the body surface of bilateral Neiguan (PC6) acupoints decreased significantly in the ISO group, compared to that of the CTL group. Conclusion: Infrared thermal imaging technology can be used to detect the changes in the energy state of acupoints. Chronic myocardial ischemic injury can cause a decrease in IR temperature on the body surface of bilateral Neiguan (PC6) acupoints, suggesting that visceral diseases can lead to changes in the energy metabolism of acupoints. other: No
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