Anion transport activity and thermotropic behavior of Band 3 are found to be altered after binding of concanavalin (Con A) to human erythrocyte ghosts and isolated Band 3. At lower Con A concentration, the rate coefficients of anion transport enhance with increasing Con A concentration, while noticeable changes of the largest calorimetric endotherm of human erythrocyte membranes termed the C transition (Band 3) can not be observed. With 50μg/ml of Con A, the rate coefficient of Con A‐modified ghosts increases 34.4% in comparison with that of normal ghosts. Binding of Con A in lower concentration to ghosts bring about increase of fluidity of lipid which maybe contribute to increase anion transport via Band 3. At higher Con A concentration, the C transition tend to lower temperature with increase in Con A concentration. the C transition is shifted from 69.25°C to 66.25°C with 2.5mg/ml Con A. It is suggested that the Con A‐modified Band 3 possess a looser structure than normal one.
Synthesis, Antimicrobial Activity and Possible Mechanism of Action of 9-Bromo--Substituted Indolizinoquinoline-5,12-dione Derivatives. -25 Title compounds of type (I) are prepared and tested for their antimicrobial activities against 9 bacterial strains. The derivatives (I) and especially (Id) show the best results against Gram-positive bacterial strains. -(WU, X.-W.; WU, Z.-P.; WANG, L.-X.; ZHANG, H.-B.; CHEN, J.-W.; ZHANG, W.; GU, L.-Q.; HUANG, Z.-S.; AN*, L.-K.; Eur. J. Med. Chem. 46 (2011) 9, 4625-4633, http://dx.
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