A new catalytic oxidation system using catalytic amounts of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert-butyl nitrite with molecular oxygen serving as the environmentally benign, terminal oxidant has been developed. This aerobic catalytic system was established for the selective oxidation of non-sterically hindered benzylic alcohols and electron-rich benzyl methyl ethers, and successfully extended to an application in the oxidative deprotection of PMB ethers to the alcohols in high selectivity.
An Efficient HCCP-Mediated Direct Amination of Quinazolin-4(3H)-ones. -A wide range of quinazolin-ones and aliphatic and aromatic primary and secondary amines is used to afford the products with mostly high yields. Aromatic amines require a higher temperature for the amination step. The reaction proceeds via the activation of the quinazolin-one with tetrachlorophosphazene in the presence of base followed by amination. Pyridopyrimidine (XII) can be applied as well. -(SHEN, Z.; HE, X.; DAI, J.; MO*, W.; HU, B.; SUN, N.; HU, X.; Tetrahedron 67 (2011) 9, 1665-1672, http://dx.
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