Hydrogen-bonded organic frameworks (HOFs) are porous materials with great potential for biological applications.T he self-assembly of HOFs and biomacromolecules, however,i sc hallenging.W er eport herein the self-assembly of nanoscale HOFs (nHOFs) to encapsulate protein for intracellular biocatalysis.T he self-assembly of tetrakis(4-amidiniumphenyl)methane and azobenzenedicarboxylate can encapsulate protein in situ to form protein@nHOFs under mild conditions.This strategy is applicable to proteins with different surface charge and molecular weight, showing ah igh protein encapsulation efficiency and minimal effect on protein activity. Acellular delivery study shows that the protein@TA-HOFs can efficiently enter cells and retain enzyme activity for biochemical catalysis in living cells for neuroprotection. Our strategy paves new avenues for interfacing nHOFs with biological settings and sheds light on expanding nHOFs as aplatform for biomacromolecule delivery and disease treatment.

Aqueous electrochemical conversion of CO2 with renewable energy is a sustainable pathway to produce carbon-neutral fuels and address the growing crisis from global warming. A key challenge in the field...

A highly stable porous organic polymer bipy-POP has been prepared from the reaction of 4,4'-bipyridine and tetrakis(4-(bromomethyl)phenyl)methane in N-methylpyrrolidone at 110°C. Bipy-POP exhibited high efficiency in catalyzing the reductive debromination of a variety of benzyl bromides in N,N-dimethylformamide with dithionite as reductive reagent. For substrates that bear electron-donating group(s) on the benzene ring, the reactions selectively afforded dibenzyl sulfone derivatives. Generally, substrates that bear an electron-withdrawing group on the benzene ring gave rise to coupling products ethane derivatives. As exceptions, F, Cl or CF 3 -contained substrates were found to selectively produce sulfone derivatives. The recyclability of bipy-POP for the catalysis of the reaction of (4-fluorophenyl) methyl bromide and diphenylmethyl bromide, which afforded the corresponding sulfone or ethane derivative, revealed that, after 40 times of repeated use, the heterogeneous catalysis did not exhibit important decrease of the activity.[a] J.

Hydrogen‐bonded organic frameworks (HOFs) are porous materials with great potential for biological applications. The self‐assembly of HOFs and biomacromolecules, however, is challenging. We report herein the self‐assembly of nanoscale HOFs (nHOFs) to encapsulate protein for intracellular biocatalysis. The self‐assembly of tetrakis(4‐amidiniumphenyl)methane and azobenzenedicarboxylate can encapsulate protein in situ to form protein@nHOFs under mild conditions. This strategy is applicable to proteins with different surface charge and molecular weight, showing a high protein encapsulation efficiency and minimal effect on protein activity. A cellular delivery study shows that the protein@TA‐HOFs can efficiently enter cells and retain enzyme activity for biochemical catalysis in living cells for neuroprotection. Our strategy paves new avenues for interfacing nHOFs with biological settings and sheds light on expanding nHOFs as a platform for biomacromolecule delivery and disease treatment.