A metal-free and mild cascade reaction of acryloylbenzamides with carboxylic acids and α-imino oxy acid is developed. It undergoes decarboxylation, radical addition, and intramolecular cyclization in the presence of visible light, providing 4-substituted-isoquinoline-1,3(2H,4H)-diones in moderate to good yields.
An efficient visible-light-mediated tandem reaction of acryloylbenzamides with alkyl boronic acids, arylsulfonylhydrazides and oxime esters is developed. The reaction proceeds the radical addition and cyclization to give various isoquinoline-1,3(2H,4H)-diones in satisfactory yields under mild conditions, which provides a good opportunity to discover new meaningful bioactive compounds.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.