An efficient visible‐light‐induced (thio)etherification of quinoxalin‐2(1H)‐ones with divergent aliphatic alcohols and thiols (primary, secondary, and tertiary) at room temperature in air has been developed. This protocol was highlighted by its mild conditions, readily available starting materials, operational simplicity, and wide functional group tolerance.magnified image
The K2S2O8-catalyzed versatile C(sp2)-C(sp3) bond formation with N-heteroaromatics and γ-lactams/amides was developed. Quinoxalin-2(1H)-one, quinoline, isoquinoline, phthalazine, and benzothiazole reacted with γ-lactams/amides to give the corresponding C(sp2)-H amidoalkylation products in moderate...
An electrochemical
method for the C(sp2)–H thioetherification of quinoxalin-2(1H)-ones with primary, secondary, and tertiary thiols has
been reported. Various quinoxalin-2(1H)-ones underwent
this thioetherification smoothly under metal- and chemical oxidant-free
conditions, affording 3-alkylthiol-substituted quinoxalin-2(1H)-ones in moderate to good yields.
A mild and practical protocol is developed for the synthesis of functionalized nitrogen-containing heteroaromatics via radical C(sp2)–H or C(sp2)–halogen alkylation.
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