The efficient construction of a coumarin-pyrrole-isoquinoline-fused pentacycle via the visible-light-promoted cyclization of 4-(isoquinolin-1-ylmethyl)-3-nitrocoumarin or Yb(OTf)3-catalyzed coupling of 4-chloro-3-nitrocoumarin and 1-methylisoquinoline is reported. This methodology has further led to the development of the concise synthesis of the lamellarin core in one, two, and three steps, as well as of lamellarin D trimethyl ether in three steps.
Synthesis of Benzofuran-Containing Spirolactones from Diarylcyclopropenones.-Benzofuran-containing spirolactones are formed by a copper-catalyzed heterodimerization of 1,2-diarylcyclopropenones followed by stepwise BBr 3-promoted demethylation. As an example, this methodology is shown for the synthesis of compound (VII). -(SYU, J.-R.; LIN, C.-H.; KUO, C.-W.; YANG*, D.-Y.; Tetrahedron Lett. 55 (2014) 6, 1207-1211, http://dx.
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