ObjectiveTo evaluate left ventricular systolic function in patients with systemic lupus erythematosus (SLE) using three-dimensional speckle tracking imaging (3D-STI). MethodsThirty patients with SLE (SLE group) and 30 healthy people (control group) were examined using 3D-STI, and their clinical characteristics were collected. The following conventional 3D parameters were obtained: left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), spherical index (SPI), left ventricular end-diastolic mass (LV EDmass), and left ventricular end-systolic mass (LV ESmass). The following 3D-STI strain parameters were obtained: global longitudinal strain (GLS), global circumferential strain (GCS), left ventricular twist angle (LVtw), torque (Tor), peak strain dispersion (PSD), and myocardial comprehensive index (MCI). Statistical analysis was used to analyze the differences in the above indicators among the groups and their correlations. ResultsLVEDV and LVEF decreased; LV EDmass and LV ESmass increased; GLS, GCS, LVtw, Tor, and MCI decreased; and PSD increased in the SLE group compared with the control group (P < 0.05). The receiver operating characteristic curve showed that the area under the curve of the MCI was the highest (0.940), the sensitivity of the Tor and MCI was the highest (90.00%), and the specificity of the Tor was the highest (93.33%). Correlation analysis showed that there was a good correlation between the MCI and hs-TropT. ConclusionThe systolic function of the left ventricle is decreased in patients with SLE. 3D-STI technology can detect abnormal left ventricular systolic function in patients with SLE in the early stage.
Objective To observe the effects of arsenic and the protective effects of 2-aminoethoxydiphenyl borate (2-APB) and dantrolene on the trabeculae of Sprague Dawley (SD) rats. Methods Thirty-six SD rats were randomly divided into a control group and an arsenic poisoning group. After 12 weeks of arsenic exposure, six rats in the arsenic poisoning group were randomly selected for sacrifice. The remaining rats were randomly assigned to four groups (n=6 per group): natural recovery after arsenic exposure, dantrolene intervention after arsenic exposure, 2-APB intervention after arsenic exposure, and 2-APB + dantrolene intervention after arsenic exposure. After 21 days of treatment by oral gavage every other day, the bilateral femurs and tibias of the rats were scanned using micro-computed tomography (micro-CT). Bone marrow stromal cells (BMSCs) were isolated and cultured, and Ca2+ concentration and alkaline phosphatase (ALP) activity of BMSCs was assessed. Results Compared with the control group, bone mineralization density (BMD), bone volume (BV)-to-total volume (TV) ratio (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), and degree of anisotropy (DA) decreased, while trabecular separation (Tb.Sp), trabecular pattern factor (TBpf), and structural model index (SMI) increased in the arsenic poisoning group (P<0.05); additionally, Ca2+ concentration increased and ALP activity decreased significantly in the arsenic poisoning group (P<0.05). Compared with the natural recovery group, after arsenic exposure, the indices of micro-CT recovered to some extent, the Ca2+ concentration of BMSCs decreased significantly, and the ALP activity of BMSCs increased significantly after intervention with 2-APB and dantrolene (P<0.05). Conclusion Arsenic can lead to significant changes in the structure of trabeculae and osteoporosis in rats, and these changes can be improved by intervention with 2-APB and dantrolene.
Purpose: We aimed to investigate the value of the tissue mitral annular displacement (TMAD) technique in evaluating left ventricular systolic function in patients with acute ST segment elevation myocardial infarction (STEMI) treated by Tongxinluo after percutaneous coronary intervention (PCI). Methods: Sixty patients with acute STEMI who underwent emergency PCI were randomly assigned to either the conventional group or the Tongxinluo group. Conventional echocardiography, two-dimensional speckle tracking imaging (2D-STI) and TMAD were performed 72 hours and 12 months after PCI. The following parameters were obtained: left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), stroke output (SV), left ventricular ejection fraction (LVEF-Simpson), global longitudinal strain of left ventricle (GLS), left ventricular global circumferential strain (GCS), septal displacement (TMAD-sep), lateral displacement (TMAD-lat), midpoint displacement (TMAD-midpt) and the percentage of TMAD to LV length from the midpoint of the mitral annulus to the apex at end-diastolic (TMAD-midpt%). And LVEF was measured by three-dimensional automated cardiac function quantification (3DQA) (LVEF-3DQA). Statistical analysis was used to analyze the differences in the above indicators among the groups and their correlations. Results: 12 months after PCI, compared with the conventional group, LVEDD, LVESD and SV decreased, LVEF-Simpson, LVEF-3DQA, GLS, GCS and TMAD parameters increased in the Tongxinluo group (P < 0.05). Correlation analysis showed that TMAD parameters were positively correlated with GLS and LVEF-3DQA, and TMAD-midpt% had the highest correlation with GLS and LVEF-3DQA (r = 0.829,P < 0.01;r = 0.754,P < 0.01), and TMAD-midpt% had good repeatability and good repeatability. Conclusion: TMAD can be used to evaluate the protective effect of Tongxinluo on left ventricular systolic function in patients with acute STEMI after PCI.
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