Local WSS values in CCAs can be measured using 3.0T MR imaging combined with image-processing techniques. Intersubject variations were found in the distribution and magnitude of wall shear stress as well as in the flow profile pattern in CCAs, which may be caused by different vessel morphologies.

two groups according to left ventricle ejection fraction (LVEF) (N group: n¼4129, LVEF>40%; L group: n¼365, LVEF#40%). Results Patients in L group was younger (60.669.72 vs 65.2610.7 years; p<0.001). There was more previous myocardial infarction (MI) and diabetes and less hypertension and hyperlipidaemia in L group. Logistic regression analysis indicated that the age, previous MI, diabetes, previous PCI and hyperlipidaemia were independent indexes to left ventricle function of triple vessel disease. Eighty-three and 2301 patients in L and N group (22.7% and 55.7%, respectively) were treated with PCI. The follow-up period of L and N groups were 5816298 and 6396293 days, respectively. MACE rate was significantly high in L group (38.6% vs 18.9%; p<0.001), which was contributed by cardiac death, no fatal MI and TVR (9.6% vs 0.9%; p<0.001, 7.2% vs 2.0%; p<0.001 and 21.7% vs 16.0%; p¼0.173, respectively). There was no difference of total stent thrombosis or its components in both groups (total: 3.9% vs 3.5%; p¼1.000, early: 0.2% vs 0.9%; p¼0.256, late: 0.7% vs 1.3%; p¼0.404 and very late: 3.1% vs 1.3%; p¼0.201, respectively). Seven month Angiographic follow-up indicated that both in-stent and in-segment restenosis rate were significantly higher in L group (21.0% vs 11.1%; p¼0.034 and 24.0% vs 12.2%; p¼0.018). Conclusion This one center, large sample study showed clinical characteristics of ischaemic cardiomyopathy, MI and diabetes might contribute to its morbidity, and PCI might prevent its morbidity. PCI of patients with triple coronary arteries disease and impaired left ventricle (LV) function leaded to worse outcomes when compared with normal LV function. Objective To investigate the clinical safety and mid-and short-term efficacy of rapamycin eluting stent (Excel) in patients with coronary artery disease. Methods Between Jul. 2006 and Jun. 2009, 240 patients of coronary heart disease received percutaneous coronary intervention (PCI) with Excel stent and were followed up from 6 to 24 months for observing the incidence of angina pectoris, myocardial infarction, sudden death and revascularization. Results 327 pieces of Excel stent were implanted in 272 target lesions (269 with de novo and 3 of restenosis), but 2 cases failed due to seriously deformed middle anterior descending artery from calcification in 1 and the angle of middle circumflex branch larger than 90 degrees in another to prevent the passage. 325 pieces of stent were successfully implanted, and the postoperative follow-up in the 8 th to 18 th month showed that angina pectoris occurred in 5, restenosis in 2 and normal in 3 by coronary arteriongraphy, suspected thrombosis in 1 at the 5 th month after the operation regarding ventricular fibrillation, haemorrhage of upper digestive tract in 4 at the 6 th month of the intervention, in which 1 underwent inpatient therapy with blood transfusion. The postoperative major coronary adverse event accounted for 4.58% between 6 and 24 months. Conclusion Excel drug-eluting stent may be excellent in treatment of coron...

Background In patients with acute myocardial infarction (AMI), percutaneous coronary intervention (PCI) for no culprit vessel is not recommended by the guidelines. However, in patients with AMI and severe multivessel disease, simultaneous PCI of both culprit and no culprit lesions may reduce ischemic burden, whereas the long term clinical outcome in patients with AMI undergoing multivessel PCI is lacking. Aims The aim of our study is to investigate the long term prognosis in patients with AMI undergoing single vessel versus multivessel PCI. Methods The documents of 1540 consecutive patients with AMI undergoing PCI from 2005 to 2008 were retrospectively screened. Patients were followed up either by telephone or outpatient visits. Clinical follow-up data were collected in 79% (n=1217) of the overall cohort. Results Culprit-vessel PCI was done in 859 patients, while 358 patients had both culprit-and no culprit-vessel PCI. Median clinical follow-up duration was 35.0 months (IQR 24.2-46.3). Age, baseline comorbidities, ejection fraction and periprocedural medications were similar between two groups. In-hospital mortality as well as vascular and bleeding complication rate was similar. During 3-years clinical follow up, Patients with multivessel PCI were associated with signifi cantly increased overall major adverse cardiac event rate (12.2% vs 17.3%, p=0.019), which was largely driven by signifi cantly higher incidence of target vessel revascularisation (4.5% vs 7.8%, p=0.022). Whereas all cause mortality (4.1% vs 5.0%, p=0.458), and non-fatal myocardial infarction (3.6% vs 4.5%, p=0.478) were comparable in patients with single vessel versus multivessel PCI. Survival analysis revealed no signifi cant differences in the composite incidence of death and myocardial infarction. Conclusion All cause mortality, myocardial infarction, inhospital vascular, and bleeding complications for multivessel PCI were no worse than for single-vessel PCI in patients with AMI, whereas target vessel revascularisation risk was increased with multivessel PCI.

Background Clinical outcomes of percutaneous coronary intervention (PCI) with drug eluting stent (DES) versus coronary artery bypass grafting (CABG) for unprotected left main (UPLM) disease in patients with diabetes according to the Global Risk Classifi cation (GRC) score has not been evaluated. Methods The clinical outcomes of 184 patients with diabetes undergoing PCI with DES for UPLM lesions were compared with the outcomes of 184 age-matched (±5 years) patients with diabetes undergoing CABG for UPLM during the same study period. Patients were followed up either by telephone or by outpatient visits. And in further analysis, we calculated the GRC score for each patient and reclassifi ed the patients into low, medium, and high risk tertile. Results Median clinical follow-up duration was 13 months. Baseline comorbidities and discharge medications were similar between two groups, except that the CABG group had more patients with bifurcation and multivessel disease, and less on August 25, 2020 by guest.

Introduction. Radiomics could be potential imaging biomarkers by capturing and analyzing the features. Children and adolescents with CHD have worse neurodevelopmental and functional outcomes compared with their peers. Early diagnosis and intervention are the necessity to improve neurological outcomes in CHD patients. Methods. School-aged TOF patients and their healthy peers were recruited for MRI and neurodevelopmental assessment. LASSO regression was used for dimension reduction. ROC curve graph showed the performance of the model. Results. Six related features were finally selected for modeling. The final model AUC was 0.750. The radiomics features can be potential significant predictors for neurodevelopmental diagnoses. Conclusion. The radiomics on the conventional MRI can help predict the neurodevelopment of school-aged children and provide parents with rehabilitation advice as early as possible.

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