Background: This study assessed the reasons for using heated tobacco products (HTPs) among South Korean adults according to demographic and socioeconomic factors. Methods: An online panel survey was conducted from November 3 to 9, 2018, including 7,000 adults (4,700 females, 2,300 males) from 70,000 age-, sex-, and provincial-distributionmatched individuals, based on the 2018 national population statistics. Females were oversampled because their tobacco use prevalence was low. The reasons for using HTPs were investigated and ranked according to age, sex, education level, monthly income, and current HTP usage status. Descriptive statistics were then presented as unweighted numbers and weighted percentages. Results: Of the 7,000 participants, 944 (16.8%) were ever HTP users. The most common reasons for using HTPs among ever HTP users were as follows: "no ash is formed (74.8%)" and "it has less odor than conventional cigarettes (71.9%)." Current HTP users responded with higher percentages for all the reasons, compared to former HTP users. HTP having "less odor than conventional cigarettes" was the most important reason for younger smokers (20-34 years old) compared with those of other age groups. No significant differences were observed in the order of reasons for HTP use between males and females. People with higher education used HTPs to "reduce conventional cigarette use" (41.4% vs. 30.9%), and people with higher income (over monthly income of 7000K won) used HTPs as it produced "less odor than conventional cigarettes" (77.2%). Conclusion:In South Korea, the most important reason for HTP use among current HTP users is the absence of ash and odor.
Cancer model systems that maintain the genetic and phenotypic characteristics of human cancers are crucial for the study of precision cancer medicine. In this respect, patient-derived cancer organoids have been developed as preclinical models of various human cancers, with significant advantages over previous cancer models including patient-derived xenografts and cell lines. We recently reported a culture system of patient-derived lung cancer organoids (LCOs) that retain the characteristics of patients’ tumors. Here, we describe a detailed protocol for establishing LCOs from surgically resected tumor tissues and endoscopic biopsy samples. This method improves the efficiency of setting up LCOs composed of pure cancer cells and describes an additional procedure for reconstructing LCOs after cryopreservation. We confirmed that stored LCOs had the ability to self-organize and retain the morphological and genetic characteristics of their parental tissues. They also maintained their responsive properties to certain anticancer drugs after thawing. In conclusion, our method efficiently generates LCOs that enable anticancer drug screening at the individual patient level.
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