This study describes a visible-light-induced cascade
reaction for
preparing cyanoalkyl-containing polyheterocycles initiated by the
photoinduced radical cascade addition of N-arylacrylamide
derivatives using cyclic oxime esters as radical sources followed
by cyanoalkyl-mediated cyclization. This protocol features outstanding
functional group compatibility, providing a variety of desired phenanthridine
derivatives in moderate to good yields. Moreover, the application
of a microflow technique enhanced these reactions compared with the
equivalent batch reaction, significantly reducing reaction times to
10 min.
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