Cytokine-induced apoptosis inhibitor 1 (CIAPIN1), known as an anti-apoptotic and signal-transduction protein, plays a pivotal role in a variety of biological processes. However, the role of CIAPIN1 in inflammation is unclear. We investigated the protective effects of CIAPIN1 in lipopolysaccharide (LPS)-exposed Raw 264.7 cells and against inflammatory damage induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in a mouse model using cell-permeable Tat-CIAPIN1. Transduced Tat-CIAPIN1 significantly reduced ROS production and DNA fragmentation in LPS-exposed Raw 264.7 cells. Also, Tat-CIAPIN1 inhibited MAPKs and NF-κB activation, reduced the expression of Bax, and cleaved caspase-3, COX-2, iNOS, IL-6, and TNF-α in LPS-exposed cells. In a TPA-induced animal model, transduced Tat-CIAPIN1 drastically decreased inflammation damage and inhibited COX-2, iNOS, IL-6, and TNF-α expression. Therefore, these findings suggest that Tat-CIAPIN1 might lead to a new strategy for the treatment of inflammatory skin disorders.
When planning for streams, adequate and definite flood control should be in the primary consideration of the planner; likewise, flood control is the basic prerequisite for the recent river restoration taking place nationwide. Planning 'safe' streams and rivers that are predictable and controllable begins from accurate survey data. In this research, we will create streams in 3D terrain models and apply them through hydraulic analysis and restoration using smart geospatial information. This process allows the extraction of more accurate data regarding streams and rivers, which makes possible precise hydraulic analysis that is superior in details to the conventional methods. The study also proposes optimal vertical section interval for efficient data processing on hydraulic analysis, applicable when LiDAR data is utilized on hydraulic analysis of urban streams. The study proposes 3D design plan and various applications for spatially planning and restoring rivers and streams.
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